{"product_id":"biolegend-375122","title":"Biolegend, 375122, PE\/Dazzle™ 594 anti-human CD159a (NKG2A) Antibody, 100tests","description":"\u003cp\u003eCD159a, also known as NKG2A or KLRC1, is a type II transmembrane protein. It belongs to the killer cell lectin-like receptor family also known as the NKG2 family. It is expressed on NK and NKT cells and T cell subsets. NKG2A is an inhibitory NK cell receptor and it is expressed as a heterodimer with CD94. In human, NKG2A\/CD94 complex interacts HLA-E on target cells and inhibits T cells and NK cell effector functions. Recent studies showed that NKG2A blockade enhances the anti-tumor effect of NK cell and CD8 + T cells.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human NKG2A\/CD94-transfectants\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Dazzle™ 594 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. * PE\/Dazzle™ 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Clone S19004C does not cross-react with mouse CD159a.\u003cbr\u003e\nProduct Citations: Rodriguez-Garcia GJ, et al. 2024. Immunohorizons. 464:8. PubMed\u003cbr\u003e\nRRID: AB_2888869 (BioLegend Cat. No. 375121) AB_2888869 (BioLegend Cat. No. 375122)\u003cbr\u003e\nStructure: Type II transmembrane proteins of the C-type lectin superfamily\u003cbr\u003e\nDistribution: NK cells, NKT cells, T cell subsets\u003cbr\u003e\nFunction: Inhibiting NK cell receptor\u003cbr\u003e\nLigand\/Receptor: HLA-E\u003cbr\u003e\nCell Type: Lymphocytes, NK cells, NKT cells, T cells\u003cbr\u003e\nBiology Area: Immuno-Oncology, Immunology\u003cbr\u003e\nMolecular Family: Immune Checkpoint Receptors\u003cbr\u003e\nAntigen References: Brooks AG, et al. 1999. J Immunol. 162:305-13. Kaiser BK, et al. 2008. Proc Natl Acad Sci U S A. 105: 6696-701. Braud VM, et al. 2003. Trends Immunol. 24:162-4. Kamiya T, et al. 2019. J Clin Invest. 129:2094. André P, et al. 2018. Cell. 175:1731.\u003cbr\u003e\nGene ID: 3821\u003cbr\u003e\nUniProt: View information about CD159a on UniProt.org\u003cbr\u003e\nClone: S19004C\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Killer Cell Lectin Like Receptor C1, KLRC1, NK Cell Receptor A\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866256527529,"sku":"375122","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-375122","provider":"Iright","version":"1.0","type":"link"}