{"product_id":"biolegend-376707","title":"Biolegend, 376707, PE\/Cyanine7 anti-human CD8b Recombinant Antibody, 25tests","description":"\u003cp\u003eCD8b or CD8β antigen is also known as T8, Lyt2, Ly-2, and CD8β. It is a member of the immunoglobulin superfamily expressed on most thymocytes, and some mature T cell subsets. CD8β forms heterodimers with the CD8α chain (CD8a). CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells. CD8 participates in T cell activation through its association with the T cell receptor complex and protein tyrosine kinase lck (p56lck).\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Recombinant\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Based on in-house testing, clone QA20A40 reacts with an epitope formed by a heterodimer of human CD8a and CD8b chains, while clone S21011A reacts to an epitope exclusively present on human CD8b.\u003cbr\u003e\nRRID: AB_3106047 (BioLegend Cat. No. 376707) AB_3106047 (BioLegend Cat. No. 376708)\u003cbr\u003e\nStructure: Ig superfamily\u003cbr\u003e\nDistribution: Most thymocytes, subset of mature T cells\u003cbr\u003e\nFunction: Co-receptor for TCR\u003cbr\u003e\nInteraction: CD8α, CD3δ, Lck\u003cbr\u003e\nLigand\/Receptor: MHC class I molecule\u003cbr\u003e\nCell Type: Lymphocytes, T cells, Thymocytes\u003cbr\u003e\nBiology Area: Adaptive Immunity, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Johnson P. 1987. Immunogenetics. 26:174-7. Norment AM \u0026amp; Littman DR, 1988. EMBO J. 7:3433-9.\u003cbr\u003e\nGene ID: 926\u003cbr\u003e\nUniProt: View information about CD8beta on UniProt.org\u003cbr\u003e\nClone: QA20A40\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Lyt3, Ly3, P37, LEU2, CD8B1 CD8b, CD8beta\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866191024297,"sku":"376707","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-376707","provider":"Iright","version":"1.0","type":"link"}