{"product_id":"biolegend-377129","title":"Biolegend, 377129, PE anti-human MRP-14 (S100A9) Antibody, 100tests","description":"\u003cp\u003eThe S100A8\/A9 complex has been shown to play a role in calcium-dependent activation and exhibits antibacterial, antifungal, immunomodulatory, and anti-proliferative effects. It also functions as a chemoattractant for neutrophils and serves as an endogenous activator of Toll-like receptor 4 (TLR4). S100A9 has been identified as a marker of CD14⁺ HLA-DR⁻\/low myeloid-derived suppressor cells (MDSCs).\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant protein of human MRP-14 (S100A9)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nRRID: AB_3720634 (BioLegend Cat. No. 377128) AB_3720634 (BioLegend Cat. No. 377129)\u003cbr\u003e\nStructure: S100A9 belongs to S100 family of proteins containing 2-EF-hand calcium-binding motifs, forms non-covalently associated complexes with another S100 family member MRP-8.\u003cbr\u003e\nDistribution: Secreted and localized to the cytoplasm and cell membrane in cells such as MDSCs, neutrophils, monocyte, and ileal tissue eosinophils\u003cbr\u003e\nFunction: Calcium-dependent activation, immunomodulating and antiproliferative, endogenous activator of Toll-like receptor 4\u003cbr\u003e\nCell Type: Eosinophils, Monocytes, Neutrophils\u003cbr\u003e\nBiology Area: Cell Adhesion, Cell Biology, Immunology, Innate Immunity, Signal Transduction\u003cbr\u003e\nMolecular Family: Adhesion Molecules\u003cbr\u003e\nAntigen References: Loser K, et al. 2010. Nat. Med. 16:713. Cheng P, et al. 2008. J. Exp. Med. 205:2235. Leukert N, et al.2006. J. Mol. Biol. 359:961. Lagasse E, et al. 1988. Mol. Cell. Biol. 8:2402. Zhao F, et al. 2012. Immunology. 136:176.\u003cbr\u003e\nGene ID: 6280\u003cbr\u003e\nUniProt: View information about MRP-14 on UniProt.org\u003cbr\u003e\nClone: A22135F\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: S100A9, Migration inhibitory factor-related proteins-14, Calgranulin-B, Leukocyte L1 complex heavy chain, Calprotectin L1H subunit\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866077745321,"sku":"377129","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-377129","provider":"Iright","version":"1.0","type":"link"}