{"product_id":"biolegend-378110","title":"Biolegend, 378110, APC\/Cyanine7 anti-human VISTA (PD-1H) Antibody, 100tests","description":"\u003cp\u003eVISTA (V-domain Ig suppressor of T cell activation), also known as PD-1H, is a type I transmembrane protein with a single extracellular IgV domain. VISTA is expressed by a subset of T cells, macrophages, dendritic cells, neutrophils, and NK cells. It was reported that in certain tumor environment, there is low-pH dependent interaction between VISTA and PSGL1. However, the physiological binding partner for VISTA and the mechanism of its action are not clearly understood. VISTA is considered as a checkpoint regulator and a promising target for cancer immunotherapy.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human VISTA protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nRRID: AB_3699020 (BioLegend Cat. No. 378109) AB_3699020 (BioLegend Cat. No. 378110)\u003cbr\u003e\nStructure: Ig V-domain like\u003cbr\u003e\nDistribution: Hematopoietic cells, monocytes, macrophages, dendritic cell, granulocytes, subsets of T cells\u003cbr\u003e\nFunction: Suppressing T cell activation\u003cbr\u003e\nCell Type: Dendritic cells, Granulocytes, Lymphocytes, Macrophages, Monocytes, T cells\u003cbr\u003e\nBiology Area: Immunology, Inhibitory Molecules\u003cbr\u003e\nAntigen References: Wang Li, et al. 2011. J Exp Med. 208:577-92. Nowak EC, et al. 2017. Immunol Rev. 276:66-79. Flies DB, et al. 2014. J Clin Invest. 124:1966-75.\u003cbr\u003e\nGene ID: 64115\u003cbr\u003e\nUniProt: View information about VISTA on UniProt.org\u003cbr\u003e\nClone: A17002B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: V-Set Immunoregulatory Receptor (VSIR), B7H5, GI24, B7-H5, Dies1, PD-1H, SISP1, VISTA, PP2135, C10orf54, DD1alpha\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864403628201,"sku":"378110","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-378110","provider":"Iright","version":"1.0","type":"link"}