{"product_id":"biolegend-378506","title":"Biolegend, 378506, APC anti-human ROR2 Antibody, 100tests","description":"\u003cp\u003eROR2 is a receptor protein tyrosine kinase that belongs to the ROR subfamily of cell surface receptors. Both canonical and non-canonical Wnt proteins bind to the ROR2 receptor. ROR2 may play a role during embryonic development in the formation of chondrocytes and cartilage and growth plate development and mediates WNT5A-induced noncanonical Wnts signaling, which induces filopodia formation and cell migration.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Transfectant AA 1-472\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nRRID: AB_3068221 (BioLegend Cat. No. 378505) AB_3068221 (BioLegend Cat. No. 378506)\u003cbr\u003e\nStructure: Single-pass type I membrane protein\u003cbr\u003e\nDistribution: Cell membrane\u003cbr\u003e\nFunction: ATP binding, coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway, Wnt protein binding, transmembrane receptor protein tyrosine kinase activity\u003cbr\u003e\nInteraction: Frizzled binding, mitogen-activated protein kinase kinase kinase binding\u003cbr\u003e\nLigand\/Receptor: Wnt5a\u003cbr\u003e\nBiology Area: Cell Motility\/Cytoskeleton\/Structure, Cell Proliferation and Viability\u003cbr\u003e\nMolecular Family: Protein Kinases\/Phosphatase\u003cbr\u003e\nAntigen References: Masiakowski P, et al. 1992. J Biol Chem. 267:26181-90. O'Connell MP, et al. 2010. Oncogene. 29:34-44. Liu Y, et al. 2008. J Cell Biochem. 105:497-502. Schwarzer W, et al. 2009. Hum Mol Genet. 18:4013-21.\u003cbr\u003e\nGene ID: 4920\u003cbr\u003e\nUniProt: View information about ROR2 on UniProt.org\u003cbr\u003e\nClone: W19338B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Tyrosine-protein kinase transmembrane receptor ROR2 , Neurotrophic tyrosine kinase, receptor-related 2,\u003cbr\u003e\nIsotype: Rat IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866415124649,"sku":"378506","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-378506","provider":"Iright","version":"1.0","type":"link"}