{"product_id":"biolegend-379102","title":"Biolegend, 379102, Purified anti-human CD248 (Endosialin) Antibody, 100μg","description":"\u003cp\u003eEndosialin, also known as Tumor Endothelial Marker 1 (TEM1), CD248 and CD164 sialomucin-like 1 (CD164L1), is classified as a C-type lectin-like protein and shares both sequence and structural 39% homology with thrombomodulin (CD141) and 33% homology to complement receptor C1qRp (CD93). CD248 is expressed on pericytes and fibroblasts during tissue development, tumor neovascularization and inflammation.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Diploid human fibroblasts\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested ICC, IHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. For immunocytochemistry, a concentration range of 5.0 - 10.0 μg\/mL is recommended. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10.0 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): 1. Teicher BA. 2019. Oncotarget. 10:993-1009. (Flow, ICC) 2. Hardie DL, et al. 2011. Immunology. 133:288-95. (IHC-P, Flow)\u003cbr\u003e\nRRID: AB_2927975 (BioLegend Cat. No. 379102)\u003cbr\u003e\nStructure: Heavily glycosylated, single-pass transmembrane protein\u003cbr\u003e\nDistribution: Endosialin is expressed on pericytes and fibroblasts during tissue development, tumor neovascularization and inflammation.\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Fibroblasts, Mesenchymal Stem Cells\u003cbr\u003e\nBiology Area: Angiogenesis, Cell Biology, Stem Cells\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Bagley RG, et al. 2009. Int J Oncol. 34:619-27. Teicher BA. 2019. Oncotarget. 10:993-1009. Teicher BA. 2007. Int J Oncol. 2007. 30:305-12. Rouleau C, et al. 2008. Clin Cancer Res. 14:7223-36.\u003cbr\u003e\nGene ID: 57124\u003cbr\u003e\nUniProt: View information about CD248 on UniProt.org\u003cbr\u003e\nClone: B1\/35\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CD248 molecule, Tumor endothelial marker 1(TEM1), CD164 sialomucin-like 1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862547812521,"sku":"379102","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-379102","provider":"Iright","version":"1.0","type":"link"}