{"product_id":"biolegend-379302","title":"Biolegend, 379302, Purified anti-human CD266 Antibody, 100μg","description":"\u003cp\u003eCD266 is a 14 kD transmembrane protein known as TWEAK receptor (TWEAK-R) or fibroblast growth factor inducible 14 (Fn14). It is member 12A of the tumor necrosis factor receptor superfamily (TNFRSF12A) expressed at low levels in a variety of tissues, such as heart, placenta, lung, muscle, and pancreas. TWEAK-R binds TWEAK (CD255) and interacts with the cytoplasmic proteins TRAF1, 2, and 3. The engagement of Fn14 can induce cell death and may play a role in inflammation, hepatocyte growth, and liver neoplasia.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: IHC-P - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10.0 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2910445 (BioLegend Cat. No. 379302)\u003cbr\u003e\nStructure: Transmembrane TNF superfamily receptor, contains no death domain, 14 kD\u003cbr\u003e\nDistribution: Widely expressed in heart, placenta, lung, muscle, kidney, pancreas, and HUVEC\u003cbr\u003e\nFunction: Binds to TWEAK (CD255), thought to play a role in cell death and inflammation\u003cbr\u003e\nLigand\/Receptor: TWEAK (CD255); interacts with cytoplasmic proteins TRAF1, 2, and 3\u003cbr\u003e\nAntigen References: Feng SL, et al. 2000. Am J Pathanol. 156:1253-61. Meighan-Mantha RL, et al. 1999. J Biol Chem. 274:33166-79. Nakayama M, et al. 2003. J Immunol. 170:341-8. Lynch CN, et al. 1999. J Biol Chem. 274:8455-9.\u003cbr\u003e\nGene ID: 51330\u003cbr\u003e\nUniProt: View information about CD266 on UniProt.org\u003cbr\u003e\nClone: A19192A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Fibroblast growth factor-inducible 14 kD protein (Fn14), TWEAK receptor, TNFRSF12A\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866067292329,"sku":"379302","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-379302","provider":"Iright","version":"1.0","type":"link"}