{"product_id":"biolegend-379702","title":"Biolegend, 379702, Purified anti-human ATG3 Antibody, 100μg","description":"\u003cp\u003eHuman autophagy related 3, ATG3, is a 314 amino acid protein with a molecular mass of 36 kD, which is a ubiquitin-like modifier similar to the canonical E2 enzyme. ATG3 is a widely expressed conjugating enzyme for APG8 lipidation, an essential step for the initiation of autophagy. Autophagy is the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway which plays an important role in controlling normal growth but may be defective in tumor cells. ATG3 is essential for autophagocytosis, which is a starvation-induced process responsible for transport of cytoplasmic proteins to the lysosome\/vacuole.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: IHC-P - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10.0 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2922609 (BioLegend Cat. No. 379702)\u003cbr\u003e\nStructure: Human ATG3 is a 314 amino acid protein with a molecular mass of 36 kD\u003cbr\u003e\nDistribution: Expressed in testis and bone marrow stromal cell\u003cbr\u003e\nFunction: E2-conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2, or MAP1LC3A).\u003cbr\u003e\nInteraction: Interacts with ATG7 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5.\u003cbr\u003e\nLigand\/Receptor: ATG8\u003cbr\u003e\nBiology Area: Cell Biology, Cell Death, Immunology\u003cbr\u003e\nMolecular Family: Apolipoproteins, Autophagosome Markers\u003cbr\u003e\nAntigen References: Isei T, et al. 2002. J Biol Chem. 277:13739. Silke M. et al. 2009. Hum Genet. 128:453. Ozlem O, et al. 2012. Apoptosis. 17:810.\u003cbr\u003e\nGene ID: 64422\u003cbr\u003e\nUniProt: View information about ATG3 on UniProt.org\u003cbr\u003e\nClone: A19237B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Autophagy Related 3\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866067325097,"sku":"379702","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-379702","provider":"Iright","version":"1.0","type":"link"}