{"product_id":"biolegend-382702","title":"Biolegend, 382702, Purified anti-human CD22 Antibody, 100μg","description":"\u003cp\u003eCD22 is a 130 kD type I transmembrane glycoprotein also known as Siglec-2 and BL-CAM and is a member of the immunoglobulin superfamily (sialoadhesion subgroup). CD22 is expressed in the cytoplasm of pro-B and pre-B cells, and on the surface of mature B and activated B cells, but not on plasma cells. CD22 is present in the B cell receptor complex and associates with SHP-1, Syk, Lck, Lyn, and phospholipase Cγ1. A primary function of CD22 is thought to be in limiting antigen receptor signaling by modulating B cell activation threshold. CD22 has been shown to bind to CD45RO and CD75, although the natural ligands for this molecule remain controversial.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: IHC-P - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5.0 - 10.0 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2927812 (BioLegend Cat. No. 382701) AB_2927812 (BioLegend Cat. No. 382702)\u003cbr\u003e\nStructure: Ig superfamily, a type I glycosylated integral transmembrane protein, 120-130 kD\u003cbr\u003e\nDistribution: B cells\u003cbr\u003e\nFunction: Adhesion, B-monocyte and B-T interactions\u003cbr\u003e\nLigand\/Receptor: CD45RO, CD75\u003cbr\u003e\nBiology Area: Cell Adhesion\u003cbr\u003e\nMolecular Family: Adhesion Molecules\u003cbr\u003e\nAntigen References: Clark E. 1993. J Immunol. 150:4715-8. Shan D, et al. 1995. J Immunol. 154:4466-75.\u003cbr\u003e\nGene ID: 933\u003cbr\u003e\nUniProt: View information about CD22 on UniProt.org\u003cbr\u003e\nClone: A21052D\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: BL-CAM, Siglec-2, Lyb8\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866074632361,"sku":"382702","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-382702","provider":"Iright","version":"1.0","type":"link"}