{"product_id":"biolegend-382902","title":"Biolegend, 382902, Purified anti-human CD83 Recombinant Antibody, 100μg","description":"\u003cp\u003eCD83, also known as B-cell activation protein and Cell surface protein HB15, is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. CD83 is expressed by activated lymphocytes, Langerhans cells and interdigitating reticulum cells. CD83 may play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Recombinant\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2927817 (BioLegend Cat. No. 382902)\u003cbr\u003e\nStructure: Ig superfamily, single chain transmembrane glycoprotein, 43 kD\u003cbr\u003e\nDistribution: Dendritic cells, Langerhan cells, activated B and T cells\u003cbr\u003e\nFunction: Membrane-bound CD83 is of immune stimulatory capacity, activates T-cells and is important for the generation of thymocytes; the soluble CD83 has the opposite effect and has an immune inhibitory capacity. The transmembrane domain of membrane-bound CD83 stabilizes MHC II, costimulatory molecules and CD28 in the membrane by antagonizing MARCH-family E3 ubiquitin ligases.\u003cbr\u003e\nInteraction: Treg, Dendritic cells, B cells\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Langerhans cells, T cells\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Zhou LJ, et al. 1992. J Immunol. 149:735-42. Zhang Z, et al. 2004. Protein Sci. 13:2819-24.\u003cbr\u003e\nGene ID: 9308\u003cbr\u003e\nUniProt: View information about CD83 on UniProt.org\u003cbr\u003e\nClone: QA21A26\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CD83, HB15, hCD83, BL11\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866195185833,"sku":"382902","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-382902","provider":"Iright","version":"1.0","type":"link"}