{"product_id":"biolegend-383304","title":"Biolegend, 383304, PE anti-human IFN-γ Antibody, 100tests","description":"\u003cp\u003eHuman interferon-gamma (IFN-γ, type II interferon) is a potent multifunctional cytokine which is secreted primarily by activated NK cells and T cells in response to antigens and other cytokines. Originally characterized based on anti-viral activities. IFN-γ also exerts tumor anti-proliferative, immunoregulatory, and proinflammatory activities. IFN-γ can upregulate MHC class I and II, and macrophage activation. This human IFN-γ antibody does not show cross-reactivity with mouse.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Li D, et al. 2023. Ann Med. 55:2189295. PubMed\u003cbr\u003e\nRRID: AB_2924583 (BioLegend Cat. No. 383303) AB_2924583 (BioLegend Cat. No. 383304)\u003cbr\u003e\nStructure: Cytokine; dimer; 20-25 kD (Mammalian)\u003cbr\u003e\nDistribution: CD8+ and CD4+ T cells, NK cells\u003cbr\u003e\nFunction: Upregulated by IL-2, FGF-basic, EGF; downregulated by vitamin D3 or DMN; labile at pH 2\u003cbr\u003e\nInteraction: T cells, B cells, macrophages, NK cells, endothelial cells, fibroblasts\u003cbr\u003e\nLigand\/Receptor: IFN-γRα (CDw119) dimerized with IFN-γRβ (AF-1)\u003cbr\u003e\nCell Type: Tregs\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Neuroinflammation, Neuroscience\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: Fitzgerald K, et al. Eds. 2001. The Cytokine FactsBook. Academic Press, San Diego. De Maeyer E, et al. 1992. Curr Opin Immunol. 4:321-6. Farrar M, et al. 1993. Annu Rev Immunol. 11:571-611. Gray P, et al. 1987. Lymphokines. 13:151.\u003cbr\u003e\nGene ID: 3458\u003cbr\u003e\nUniProt: View information about IFN-gamma on UniProt.org\u003cbr\u003e\nClone: W19227A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Interferon-γ, Immune interferon, Type II interferon, T cell interferon, Macrophage-activating factor (MAF), IFN-g, IFN-gamma\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866347163817,"sku":"383304","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-383304","provider":"Iright","version":"1.0","type":"link"}