{"product_id":"biolegend-384502","title":"Biolegend, 384502, Purified anti-human Bcl11b Antibody, 100μg","description":"\u003cp\u003eThe transcription factor, Bcl11b, is expressed in the thymus, mainly T cells. It is indispensable for T lineage development. When Bcl11b was deleted, T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell-associated gene expression. These induced T-to-natural killer (ITNK) cells, which were morphologically and genetically similar to conventional NK cells, killed tumor cells in vitro , and effectively prevented tumor metastasis in vivo . Therefore, ITNKs may represent a new cell source for cell-based therapies.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: RP 1-250 (generated by E. coli)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: ICFC - Quality testedWB, IHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2941561 (BioLegend Cat. No. 384502)\u003cbr\u003e\nStructure: 894 amino acids with molecular weight of 96 kD. It encodes a C2H2-type zinc finger protein and is closely related to BCL11A.\u003cbr\u003e\nDistribution: Nucleus\u003cbr\u003e\nFunction: Tumor-suppressor protein involved in T-cell lymphomas. A key regulator of both differentiation and survival during thymocyte development.\u003cbr\u003e\nInteraction: Interacts with TFCOUP1, SIRT1, ARP1, and EAR2\u003cbr\u003e\nAntigen References: Liu P, et al. 2011. Immunol Rev. 238:138-49. Ikawa T, et al. 2010. Science. 329:93-6. Li L, et al. 2010. Science. 329:89-93. Li P, et al. 2010. Science. 329:85-9. Tydell CC, et al. 2007. J Immunol. 179:4238. Avram D, et al. 2002. Biochem J. 368:555-63.\u003cbr\u003e\nGene ID: 19882\u003cbr\u003e\nUniProt: View information about Bcl11b on UniProt.org\u003cbr\u003e\nClone: W17189A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CTIP-2, CTIP2, hRIT1-alpha, SMARCM2\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866314985641,"sku":"384502","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-384502","provider":"Iright","version":"1.0","type":"link"}