{"product_id":"biolegend-384608","title":"Biolegend, 384608, APC anti-human IL-27Rα Antibody, 100tests","description":"\u003cp\u003e69 kD glycosylated transmembrane subunit of IL-27 receptor complex consisting of IL27Ra (WSX-1, TCCR) and gp130 (CD130). Expressed on T cells, monocytes, and neutrophils and aside from its effect on innate immunity, is involved in dampening the extent of Th1 immune response post infection. Activity levels of IFN -γ and IL-17 producing T cells are regulated through this receptor which relays signal through Jak-STAT pathway.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human IL-27Rα transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nRRID: AB_2936771 (BioLegend Cat. No. 384607) AB_2936771 (BioLegend Cat. No. 384608)\u003cbr\u003e\nDistribution: T cells, B cells, monocytes\u003cbr\u003e\nFunction: γ\u003cbr\u003e\nInteraction: STAT1\u003cbr\u003e\nLigand\/Receptor: IL27Ra combines with gp130 to form a receptor complex whose activation by IL-27 leads to differing pathway-dependent effector activities.\u003cbr\u003e\nCell Type: Monocytes, Neutrophils, T cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: Takeda A, et al. 2003. J Immunol. 170:4886-90. Yoshida H and Hunter CA. 2015. Annu Rev Immunol. 33:417-43. Iwasaki Y, et al. 2015. Int J Mol Sci. 16:2851-63.\u003cbr\u003e\nGene ID: 9466\u003cbr\u003e\nUniProt: View information about IL-27Ralpha on UniProt.org\u003cbr\u003e\nClone: W16093B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: IL-27RA, WSX-1, TCCR\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866303615145,"sku":"384608","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-384608","provider":"Iright","version":"1.0","type":"link"}