{"product_id":"biolegend-384902","title":"Biolegend, 384902, Purified anti-human CD27 Antibody, 100μg","description":"\u003cp\u003eCD27, also known as S152 and T14, is a 50-55 kD type I membrane protein. It is a lymphocyte-specific member of the TNF-receptor superfamily. CD27 is expressed on medullary thymocytes, virtually all mature T cells, some B cells, and NK cells. CD27 binds to CD70 and plays an important role in costimulation of T cell activation, and regulation of B cell differentiation and proliferation. The cytoplasmic domains of CD27 have also been shown to interact with TRAF2 and TRAF5 to elicit NF-κB and SAPK\/JNK activation.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Hu CD27 transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone S20020G is able to completely block the binding of clones M-T271 and O323 on target cells. Clone S20020G does not block binding of clone S20020H on target cells.\u003cbr\u003e\nRRID: AB_2941564 (BioLegend Cat. No. 384902)\u003cbr\u003e\nStructure: TNF-R superfamily, type I transmembrane glycoprotein, 50-55 kD\u003cbr\u003e\nDistribution: Medullary thymocytes, T and B cell subsets, NK cells\u003cbr\u003e\nFunction: T cell costimulation\u003cbr\u003e\nInteraction: TRAF2, TRAF5\u003cbr\u003e\nLigand\/Receptor: CD70\u003cbr\u003e\nCell Type: B cells, Lymphocytes, NK cells, T cells\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Camerini D, et al. 1991. J Immunol. 147:3156 Hintzen R, et al. 1994. Immunol Today. 15:307-11.\u003cbr\u003e\nGene ID: 939\u003cbr\u003e\nUniProt: View information about CD27 on UniProt.org\u003cbr\u003e\nClone: S20020G\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: S152, T14, TNFRSF7\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866269503657,"sku":"384902","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-384902","provider":"Iright","version":"1.0","type":"link"}