{"product_id":"biolegend-387320","title":"Biolegend, 387320, APC\/Cyanine7 anti-human CD8b Antibody, 100tests","description":"\u003cp\u003eCD8b or CD8β antigen is also known as Lyt3, or Ly-3. It is a member of the immunoglobulin superfamily expressed on most thymocytes, and some mature T cell subsets. CD8β forms heterodimers with the CD8α chain (CD8a). CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells. CD8 participates in T cell activation through its association with the T cell receptor complex and protein tyrosine kinase LCK (p56 lck ).\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nImmunogen: Human CD8α\/CD8β-transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: Clone S21011A does not interfere with the binding of CD8α binding antibodies (SK1, HIT8a, RPA-T8).Clone S21011A shows comparable staining signals on 4% paraformaldehyde-fixed cells and unfixed cells.Based on in-house testing, clone S21011A clone reacts with an epitope that is exclusively present on human CD8b, whereas clone QA20A40 reacts with an epitope formed by a heterodimer of human CD8a and CD8b chains.\u003cbr\u003e\nRRID: AB_3717009 (BioLegend Cat. No. 387319) AB_3717009 (BioLegend Cat. No. 387320)\u003cbr\u003e\nStructure: Ig superfamily\u003cbr\u003e\nDistribution: Subset of T Cells, most thymocytes\u003cbr\u003e\nFunction: TCR co-receptor\u003cbr\u003e\nInteraction: CD8α\u003cbr\u003e\nLigand\/Receptor: MHC Class 1 molecules\u003cbr\u003e\nCell Type: Lymphocytes, T cells, Thymocytes\u003cbr\u003e\nBiology Area: Adaptive Immunity, Cancer Biomarkers, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, TCRs\u003cbr\u003e\nAntigen References: Johnson P. 1987. Immunogenetics. 26:174-7. Norment AM \u0026amp; Littman DR, 1988. EMBO J. 7:3433-9.\u003cbr\u003e\nGene ID: 926\u003cbr\u003e\nUniProt: View information about CD8beta on UniProt.org\u003cbr\u003e\nClone: S21011A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Lyt3, Ly3, P37, LEU2, CD8B1, CD8b, CD8beta\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866273009833,"sku":"387320","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-387320","provider":"Iright","version":"1.0","type":"link"}