{"product_id":"biolegend-389402","title":"Biolegend, 389402, Purified anti-human CD1c Antibody, 100μg","description":"\u003cp\u003eCD1c, also known as R7 or M241, is a 43 kD member of the five CD1 antigens (CD1a-e) in humans. The CD1 molecules are type I glycoprotein with structural similarities to MHC class I and are non-covalently associated with β 2 -microglobulin, belonging to the Ig superfamily. CD1c is expressed on cortical thymocytes, Langerhans cells, dendritic cells, and a subset of B cells. It has been reported that CD1c is also expressed on mature T cells in a tightly regulated manner. CD1c is involved in antigen-presentation of glycolipids. It may also act in T cells as an immune regulatory molecule.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: RBL1 cells expressing 1-328\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_3097363 (BioLegend Cat. No. 389402)\u003cbr\u003e\nStructure: 3 kD, Ig superfamily, MHC I-like molecule, associates with β2-microglobulin\u003cbr\u003e\nDistribution: B cell subset, cortical thymocytes, dendritic cells, and Langerhans cells\u003cbr\u003e\nFunction: Presents lipid antigen to CD1c-restricted T cells\u003cbr\u003e\nInteraction: Expressed on B cells in lymph nodes, spleen, and blood\u003cbr\u003e\nLigand\/Receptor: CD1c-restricted TCR\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Langerhans cells, Thymocytes\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nGene ID: 911\u003cbr\u003e\nUniProt: View information about CD1c on UniProt.org\u003cbr\u003e\nClone: W18077D\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: R7, M241, BDCA-1, CD1\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866332811433,"sku":"389402","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-389402","provider":"Iright","version":"1.0","type":"link"}