{"product_id":"biolegend-390553","title":"Biolegend, 390553, PE anti-human CD202b (Tie2\/Tek) Antibody, 25tests","description":"\u003cp\u003eCD202b, also known as Tie2 or TEK, is a 145 kD type I transmembrane protein. It is a member of the receptor tyrosine kinase (RTK) family of proteins and is expressed by endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes. Angiopoietin-1 (Ang-1) is an activator of CD202b to promote, maintain, and stabilize mature vessels and to maintain HSCs in quiescent state. Ang-2 is another ligand of CD202b, which is involved in postnatal angiogenesis and in antagonizing the effects of Ang-1. Tie2 binds to Ang-4 as well.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant extracellular domain of human Tie2\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Clone A19069E partially block the staining of reference clone 33.1 ​Recombinant protein completely blocks the staining of test clone A19069E\u003cbr\u003e\nRRID: AB_3675121 (BioLegend Cat. No. 390553) AB_3675121 (BioLegend Cat. No. 390554)\u003cbr\u003e\nStructure: 145 kD type I transmembrane protein, receptor tyrosine kinase (RTK) family\u003cbr\u003e\nDistribution: Endothelial cells, subsets of hematopoietic stem cells and and a subset of monocytes\u003cbr\u003e\nFunction: Angiogenesis, hemotopoiesis, monocytes chemotaxis\u003cbr\u003e\nInteraction: Endothelial cells, hematopoietic stem and progenitors, monocytes\u003cbr\u003e\nLigand\/Receptor: Angiopoietin-1 (Ang-1), Ang-2, and Ang-4\u003cbr\u003e\nCell Type: Endothelial cells, Hematopoietic stem and progenitors, Monocytes\u003cbr\u003e\nBiology Area: Angiogenesis, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: De Palma M, et al. 2005. Cancer Cell. 8:211-26. Shaw JP, et al. 2004. Blood Cells Mol Dis. 32:168-75. Hsu HC, et al. 2000. Blood. 96:3757-62. Arai F, et al. 2004. Cell. 118:149-61.\u003cbr\u003e\nGene ID: 7010\u003cbr\u003e\nUniProt: View information about CD202b on UniProt.org\u003cbr\u003e\nClone: A19069E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866066768041,"sku":"390553","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-390553","provider":"Iright","version":"1.0","type":"link"}