{"product_id":"biolegend-390704","title":"Biolegend, 390704, Purified anti-human CD262 (DR5, TRAIL-R2) Antibody, 100μg","description":"\u003cp\u003eDR5, also known as TRAIL-R2, TRICK2, KILLER, and CD262, is 55 kD member 10B of the TNF receptor superfamily (TNFRSF10B). It binds the cytotoxic ligand, TRAIL, and induces apoptosis. The DR5 receptor is broadly expressed on a variety of normal tissues and many tumors. DR5 expression has been reported to be upregulated in human cells by interferon-α, 2-methoxyestradiol, and paclitaxel, and downregulated by adenoviral E3 proteins.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant Human TNFRSF10B\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality testedICC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. For immunocytochemistry, a concentration of 5.0 μg\/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone A21121I does not block the staining of reference clone DJR2-4 (7-8)Recombinant protein completely blocks the staining of test clone A21121I.\u003cbr\u003e\nRRID: AB_3662368 (BioLegend Cat. No. 390704)\u003cbr\u003e\nStructure: TNFR superfamily, 55 kD\u003cbr\u003e\nDistribution: Broadly expressed on normal and tumor cells\u003cbr\u003e\nFunction: Induces apoptosis\u003cbr\u003e\nLigand\/Receptor: TRAIL\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: MacFarlane M, et al. 1997. J Biol Chem. 272:25417-20. Walczak H, et al. 1997. EMBO J. 16:5386-97. Shigeno M, et al. 2003. Oncogene. 22:1653-62. LaVallee TM, et al. 2003. Cancer Res. 63:468-75. Nimmanapalli R, et al. 2001. Cancer Res. 61:759-63.\u003cbr\u003e\nGene ID: 8795\u003cbr\u003e\nUniProt: View information about CD262 on UniProt.org\u003cbr\u003e\nClone: A21121I\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: TRAIL-R2, KILLER, TRICK2, TNFRSF10B, Ly98, CD262\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866075254953,"sku":"390704","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-390704","provider":"Iright","version":"1.0","type":"link"}