{"product_id":"biolegend-390806","title":"Biolegend, 390806, PE anti-human\/mouse Galectin-9 Antibody, 100tests","description":"\u003cp\u003eGalectin-9 is a mammalian lectin with a molecular weight around 50 kD. It is a member of the β-galactoside-binding family. With two conserved carbohydrate recognition domains (CRDs), galectin-9 binds small β-galactosides as well as complex glycoconjugates. HAVCR2\/TIM3 has been reported as one of its ligands. Galectin-9 may be retained intracellularly or transported to the cell surface where it can be cleaved to generate a soluble form. Galectin-9 is expressed by lymphocytes, dendritic cells, granulocytes, eosinophils, astrocytes, endothelial cells, fibroblasts, and thymus epithelial cells. It can be induced by cytokines in various cell types and is involved in cell aggregation, adhesion, chemotaxis, and apoptosis. Galectin-9 induces regulatory T cells and suppresses Th1 and Th17 responses.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human galectin-9 protein (a.a 2-323)\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested FC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular flow cytometry using our Cyto-Fast™ Fix\/Perm Buffer Set. For flow cytometric staining, the suggested use of this reagent is 5 µL per 106 cells in 100 µL volume. It is highly recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Clone W21101F does not block the staining of reference clone 9M1-3. Recombinant protein completely blocks the staining of test clone W21101F.\u003cbr\u003e\nRRID: AB_3662288 (BioLegend Cat. No. 390805) AB_3662288 (BioLegend Cat. No. 390806)\u003cbr\u003e\nStructure: Member of the β-galactoside-binding lectin family. Molecular weight around 50 kD. Binds small β-galactosides as well as complex glycoconjugates with two conserved carbohydrate recognition domains (CRDs).\u003cbr\u003e\nDistribution: Lymphocytes, dendritic cells, neutrophils, eosinophils, astrocytes, endothelial cells, fibroblasts, thymus stromal\/epithelial cells\u003cbr\u003e\nFunction: Cell aggregation, adhesion, chemotaxis, apoptosis, suppression of Th1 and Th17 responses, and induction of regulatory T cells\u003cbr\u003e\nInteraction: Astrocytes, dendritic cells, endothelial cells, eosinophils, epithelial cells, fibroblasts, lymphocytes, neutrophils, tregs\u003cbr\u003e\nLigand\/Receptor: HAVCR2\/TIM3\u003cbr\u003e\nCell Type: Astrocytes, Dendritic cells, Endothelial cells, Eosinophils, Epithelial cells, Fibroblasts, Lymphocytes, Neutrophils, Tregs\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Adhesion, Cell Biology, Cell Motility\/Cytoskeleton\/Structure, Immunology\u003cbr\u003e\nMolecular Family: Adhesion Molecules, Immune Checkpoint Receptors\u003cbr\u003e\nAntigen References: Seki M, et al. 2008. Clin Immunol. 127:78-88. Tsuboi Y, et al. 2007. Clin Immunol. 124:221-33. Zhu C, et al. 2005. Nat Immunol. 6:1245-52. Dunphy JL, et al. 2002. J Biol Chem. 277:14916-24.\u003cbr\u003e\nGene ID: 8795\u003cbr\u003e\nUniProt: View information about Galectin-9 on UniProt.org\u003cbr\u003e\nClone: W21101F\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Lgals9, Gal-9, Ecalectin, Tumor antigen HOM-HD-21, Ecalectin\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866429935785,"sku":"390806","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-390806","provider":"Iright","version":"1.0","type":"link"}