{"product_id":"biolegend-391403","title":"Biolegend, 391403, PE anti-human CXCR7 Antibody, 25tests","description":"\u003cp\u003eCXCR7, also known as RDC1, belongs to a subgroup of C-X-C chemokine receptors, which are part of a large protein family of G protein-coupled receptors (GPCR). CXCR7 binds with a high-affinity to CXCL12\/SDF-1 and CXCL11\/I-TAC, which regulates the trafficking and activation of leukocytes. It is also a co-receptor for the entry of HIV-1. The binding of a ligand to CXCR7 induces proliferation and migration of immature neurons, glia, and their precursors. CXCR7 expression occurs on a wide variety of tissues and cells including monocytes, B cells, T cells, and mature dendritic cells. Surface expression of CXCR7 has been also reported in tumor cells, activated endothelial cells, and fetal liver cells.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Ando M, et al. 2021. Cancer Res Commun. 1:41. PubMed Al-Ofi EA, et al. 2018. Folia Morphol (Warsz). 10:78. PubMed Okamoto D, et al. 2022. Genes Cells. 27:368. PubMed Doijen J, et al. 2017. PLoS One. 10.1371\/journal.pone.0185354. PubMed\u003cbr\u003e\nRRID: AB_2565680 (BioLegend Cat. No. 391403) AB_2565681 (BioLegend Cat. No. 391404)\u003cbr\u003e\nStructure: G Protein-Coupled Receptor super family\u003cbr\u003e\nDistribution: Monocytes, B cells, T cells, and mature dendritic cells.\u003cbr\u003e\nFunction: Regulates trafficking and activation of leukocytes.\u003cbr\u003e\nLigand\/Receptor: CXCL12\/SDF-1 and CXCL11\/I-TAC.\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Monocytes, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Signal Transduction\u003cbr\u003e\nMolecular Family: CD Molecules, Cytokine\/Chemokine Receptors, GPCR\u003cbr\u003e\nAntigen References: 1. Torossian F, et al. 2014. Blood 123:191. 2. Walentowicz-Sadlecka M, et al. 2014. PLoS One 1:e84629. 3. Yates TJ, et al. 2013. Cancer 119:61. 4. Burns JM, et al. 2006. J. Exp. Med. 203:2201. 5. Infantino S, et al. 2006. J. Immunol. 176:2197.\u003cbr\u003e\nGene ID: 57007\u003cbr\u003e\nUniProt: View information about CXCR7 on UniProt.org\u003cbr\u003e\nClone: 10D1-J16\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Chemokine (C-X-C motif) receptor 7, RDC1, CMKOR1, GPR159, ACKR3\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860779421865,"sku":"391403","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-391403","provider":"Iright","version":"1.0","type":"link"}