{"product_id":"biolegend-392118","title":"Biolegend, 392118, Spark NIR™ 685 anti-human P2RY12 Antibody, 100tests","description":"\u003cp\u003eP2RY12 is a receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system and is not activated by UDP and UTP. P2RY12 is required for normal platelet aggregation and blood coagulation, and is a target to inhibit of platelet aggregation in the treatment of thromboembolisms and other clotting disorders. P2RY12 is expressed on platelets, lung, appendix, pituitary and adrenal glands; this molecule is a very useful marker to identify microglial cells in the brain.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human P2RY12-transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Spark NIR™ 685 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. * Spark NIR™ 685 has a maximum excitation of 665 nm and a maximum emission of 685 nm.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: View the video of our collaborator discussing the importance of highly specific monoclonal antibodies for P2RY12 in Microglia research.\u003cbr\u003e\nRRID: AB_3662290 (BioLegend Cat. No. 392117) AB_3662290 (BioLegend Cat. No. 392118)\u003cbr\u003e\nDistribution: Platelets, microglia\u003cbr\u003e\nFunction: Inhibit the adenylyl cyclase second messenger system\u003cbr\u003e\nLigand\/Receptor: ADP, ATP\u003cbr\u003e\nCell Type: Microglia, Platelets\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: GPCR, Purinergic Receptors\u003cbr\u003e\nAntigen References: 1. Lecchi A, et al. 2015. Blood. 125:1006. 2. Zhang K, et al. 2014. Nature. 509:115. 3. Zhang J, et al. 2014. Nature. 509:119. 4. Cornelissen I, et al. 2010. Proc. Natl. Acad. Sci. USA. 107:18605. 5. Paruchuri S, et al. 2009. J. Exp. Med. 206:2543.\u003cbr\u003e\nGene ID: 64805\u003cbr\u003e\nUniProt: View information about P2RY12 on UniProt.org\u003cbr\u003e\nClone: S16001E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12 platelet ADP receptor, purinergic receptor P2RY12, purinergic receptor P2Y, G-protein coupled\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866221367465,"sku":"392118","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-392118","provider":"Iright","version":"1.0","type":"link"}