{"product_id":"biolegend-392502","title":"Biolegend, 392502, Purified anti-human CD19 Antibody, 100μg","description":"\u003cp\u003eCD19 is a 95 kD type I transmembrane glycoprotein also known as B4. It is a member of the immunoglobulin superfamily expressed on B-cells (from pro-B to blastoid B cells, absent on plasma cells) and follicular dendritic cells. CD19 is involved in B cell development, activation, and differentiation. CD19 forms a complex with CD21 (CR2) and CD81 (TAPA-1), and functions as a BCR co-receptor.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human Chronic Lymphocytic Leukemia (CLL) cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone 4G7 partially blocks anti-human CD19 clones HIB19 and SJ25C1 staining based on in-house testing\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Cabezudo E, et al. 1999. Haematologica. 84:413-8 Van Zelm MC et al. 2010. J Clin Invest. 120:1265-74\u003cbr\u003e\nProduct Citations: Gehlert CL, et al. 2022. Front Immunol. 13:957874. PubMed Nugent JL, et al. 2021. iScience. 24:103421. PubMed Winterberg D, et al. 2021. J Clin Med. 10:. PubMed\u003cbr\u003e\nRRID: AB_2721738 (BioLegend Cat. No. 392502)\u003cbr\u003e\nStructure: Ig superfamily, type I transmembrane glycoprotein, 95 kD\u003cbr\u003e\nDistribution: Normal and malignant B lymphocytes\u003cbr\u003e\nFunction: B cell activation and differentiation\u003cbr\u003e\nLigand\/Receptor: Forms complex with CD21 (CR2) and CD81 (TAPA-1), BCR coreceptor\u003cbr\u003e\nCell Type: B cells, Lymphocytes\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Tedder T, et al. 1994. Immunol. Today 15:437. Bradbury L, et al. 1993. J. Immunol. 151:2915.\u003cbr\u003e\nGene ID: 930\u003cbr\u003e\nUniProt: View information about CD19 on UniProt.org\u003cbr\u003e\nClone: 4G7\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nWorkshop: HCDM listed\u003cbr\u003e\nOther Names: B4, CVID3\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862416937129,"sku":"392502","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-392502","provider":"Iright","version":"1.0","type":"link"}