{"product_id":"biolegend-393702","title":"Biolegend, 393702, Purified anti-human CD110 Antibody, 100μg","description":"\u003cp\u003eCD110 is a type I transmembrane glycoprotein which functions as a receptor for thrombopoietin; binding causes the proliferation and differentiation of megakaroyocytes in addition to the production of platelets and protection of stem cells from apoptosis. CD110 is primarily expressed on hematopoietic stem cells, hematopoietic precursor cells, cells of the megakaryocytic lineage, and platelets.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human CD110 transfectants\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Xu L, et al. 2020. Nat Cell Biol. 1162:22. PubMed\u003cbr\u003e\nRRID: AB_2750048 (BioLegend Cat. No. 393701) AB_2750049 (BioLegend Cat. No. 393702)\u003cbr\u003e\nStructure: Type I transmembrane glycoprotein\u003cbr\u003e\nDistribution: Hematopoietic stem cells, a subfraction of hematopoietic precursor cells, cells of the megakaryocytic lineage, and platelets.\u003cbr\u003e\nFunction: Megakaryocytopoiesis and platelet formation\u003cbr\u003e\nInteraction: THPO, ATXN2L, JAK2\u003cbr\u003e\nLigand\/Receptor: Thrombopoietin\u003cbr\u003e\nCell Type: Hematopoietic stem and progenitors, Megakaryocytes, Platelets\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Ninos JM, et al. 2006. J. Transl. Med. 16:4-9. Broudy VC, et al. 1996. Blood. 88:2026-32. Wang X, et al. 2016. Blood. 127:3398-409.\u003cbr\u003e\nGene ID: 4352\u003cbr\u003e\nUniProt: View information about CD110 on UniProt.org\u003cbr\u003e\nClone: S16017E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: TPOR, c-MPL, MPLV\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866226479273,"sku":"393702","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-393702","provider":"Iright","version":"1.0","type":"link"}