{"product_id":"biolegend-395403","title":"Biolegend, 395403, PE anti-human TSPAN33 (BAAM) Antibody, 25tests","description":"\u003cp\u003eTSPAN33, also known as BAAM, is a 32 kDa protein member of the TM4 superfamily (TM4SF). TSPAN33 have four transmembrane regions and two extracellular loops, one of them is a cysteine-rich long extracellular loop (LEL), characteristic of the TM4SF. TSPAN33 interacts with different molecules such as integrins and other tetraspanins. TSPAN33 is expressed by activated B cells, some B cell lymphomas, macrophages and in cells from the convoluted tubules and collecting ducts in the kidney. In macrophages TSPAN33 modulates TLR-induced proinflammatory gene expression, but its function in other cells is unknown.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human TSPAN33-transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nProduct Citations: Ando S, et al. 2017. J Immunol. 198:1210. PubMed\u003cbr\u003e\nRRID: AB_2783316 (BioLegend Cat. No. 395404)\u003cbr\u003e\nStructure: Member of the TM4 superfamily, TspanC8 subgroup, 32kD, 4 transmembrane regions, 1 cysteine-rich long extracellular loop (LEL).\u003cbr\u003e\nDistribution: Activated B cells, some B cell lymphomas, macrophages, convoluted tubules and collecting ducts from kidney\u003cbr\u003e\nFunction: Modulates TLR-induced proinflammatory gene expression\u003cbr\u003e\nCell Type: B cells, Macrophages\u003cbr\u003e\nBiology Area: Cancer Biomarkers, Immuno-Oncology, Signal Transduction\u003cbr\u003e\nMolecular Family: Adhesion Molecules\u003cbr\u003e\nAntigen References: Pérez-Martínez CA, et al. 2017. Scand J Immunol. 86:23. Ruiz-García A, et al. 2016. J Immunol. 197:3371. Luu VP, et al. 2013. Clin Immunol. 149:388. Chen Z, et al. 2005. Cancer Genet Cytogenet. 162:95. Maecker HT et al. 1997. FASEB J. 11:428.\u003cbr\u003e\nGene ID: 340348\u003cbr\u003e\nUniProt: View information about TSPAN33 on UniProt.org\u003cbr\u003e\nClone: SA17RN1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Tetraspanin-33, BAAM, Penumbra, PEN\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866283364521,"sku":"395403","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-395403","provider":"Iright","version":"1.0","type":"link"}