{"product_id":"biolegend-395614","title":"Biolegend, 395614, Spark Red™ 718 anti-human CD7 Antibody, 100tests","description":"\u003cp\u003eCD7 is a 40 kD type I transmembrane glycoprotein also known as gp40. It is a member of the immunoglobulin superfamily found on T cells, NK cells, thymocytes, hematopoietic progenitors, and monocytes (weakly). CD7 is also expressed on acute lymphocytic leukemia (ALL) and some acute myeloid leukemia (AML) cells. CD7 crosslinking induces a calcium flux in T lymphocytes, presumably as a result of cytoplasmic domain association with PI3-kinase. CD7 costimulation can induce cytokine secretion and modulate cellular adhesion.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: T-ALL blast cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Spark Red™ 718 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. * Spark Red™ 718 has a maximum excitation of 697 nm and a maximum emission of 711 nm.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nRRID: AB_3717201 (BioLegend Cat. No. 395613) AB_3717201 (BioLegend Cat. No. 395614)\u003cbr\u003e\nStructure: Ig superfamily, type I transmembrane glycoprotein, 40 kD\u003cbr\u003e\nDistribution: T cells, NK cells, thymocytes, hematopoietic progenitors, myeloid leukemic cell subsets\u003cbr\u003e\nFunction: T cell activation\u003cbr\u003e\nLigand\/Receptor: Cytoplasmic domain associates with P13-kinase\u003cbr\u003e\nCell Type: Hematopoietic stem and progenitors, Leukemia, NK cells, T cells, Thymocytes\u003cbr\u003e\nBiology Area: Costimulatory Molecules, Immunology\u003cbr\u003e\nMolecular Family: CD Molecules\u003cbr\u003e\nAntigen References: Barclay N, et al. 1993. The Leucocyte Antigen FactsBook. Academic Press Inc. San Diego. Stillwell R and Bierer BE. 2001. Immunol Res. 24:31-52. Rabinowich H, et al. 1994. J Immunol. 152:517-26.\u003cbr\u003e\nGene ID: 924\u003cbr\u003e\nUniProt: View information about CD7 on UniProt.org\u003cbr\u003e\nClone: 4H9\/CD7\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: gp40\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862419132585,"sku":"395614","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-395614","provider":"Iright","version":"1.0","type":"link"}