{"product_id":"biolegend-395804","title":"Biolegend, 395804, PE anti-human β2-microglobulin Antibody, 100tests","description":"\u003cp\u003eβ2-microglobulin (β2M) is a 12 kD nonpolymorphic Ig like protein. It is a non-membrane-anchored glycoprotein and is noncovalently associated with 39-44 kD polymorphic heavy chains of MHC class I molecules to form HLA class I antigen complex. In association with HLA class I, β2M is expressed on all leukocytes, platelets, endothelial cells, and epithelial cells. β2M plays an essential role both in governing MHC class I molecules stability and in promoting antigen binding and presenting the antigen to CD3\/TCR complex of CD8 + T cells.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human Beta2-microglobulin\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nApplication Notes: Based on in-house testing, staining for clone A17082E is not blocked by clone W6\/32 (anti-HLA-A,B,C) and is only partially blocked by clone 2M2 also raised against human ß2-microglobulin.\u003cbr\u003e\nRRID: AB_2783319 (BioLegend Cat. No. 395803) AB_2783320 (BioLegend Cat. No. 395804)\u003cbr\u003e\nStructure: 12KD, Ig like structure\u003cbr\u003e\nDistribution: Leukocytes, platelets, endothelial cells, epithelial cells and other nucleated cells.\u003cbr\u003e\nFunction: Form MHC class I\u003cbr\u003e\nInteraction: MHC class I heavy chain and other MHC I like molecules.\u003cbr\u003e\nCell Type: Endothelial cells, Epithelial cells, Leukocytes, Platelets\u003cbr\u003e\nAntigen References: Engelhard VH. 1994. Curr Opin Immunol. 6:13. Williams DB, et al. 1989. J Immunol. 142:2796. Danliczyk UG and TL. Delovitch. 1994. J Immunol. 153:3533. Williams A, et al. 2002. Tissue Antigens. 59:3.\u003cbr\u003e\nGene ID: 567\u003cbr\u003e\nUniProt: View information about beta2-microglobulin on UniProt.org\u003cbr\u003e\nClone: A17082E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: β2M, β2-M, beta2-microglobulin b2-M, b2M\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003cbr\u003e\nQ: What type of PE do you use in your conjugates?\u003cbr\u003e\nA: We use R-PE in our conjugates.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866050580649,"sku":"395804","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-395804","provider":"Iright","version":"1.0","type":"link"}