{"product_id":"biolegend-396807","title":"Biolegend, 396807, PE\/Cyanine7 anti-human CD210b (IL-10RB) Antibody, 25tests","description":"\u003cp\u003eCD210b is a Type 1 transmembrane glycoprotein also known as, subunit 2 (IL-10R2) and is an essential chain for the IL-10 receptor complex. The IL-10 receptor complex is made up of alpha (IL10-RA) and beta (IL-10RB) subunits. Coexpression of these subunits has been shown to be required for IL10 induced signal transduction. Binding of dimeric IL-10 to two alpha subunits can cause the recruitment of two beta subunits resulting in the transduction of the intracellular JAK\/STAT pathway.\u003cbr\u003e\n25tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human IL10RB-transfected cells\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with PE\/Cyanine7 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)Green Laser (532 nm)\/Yellow-Green Laser (561 nm)\u003cbr\u003e\nRRID: AB_2927901 (BioLegend Cat. No. 396807) AB_2927901 (BioLegend Cat. No. 396808)\u003cbr\u003e\nStructure: Type 1 transmembrane glycoprotein belonging to the cytokine receptor family.\u003cbr\u003e\nDistribution: CD210b is expressed by a variety of cell types including T cells, B cells, NK cells, monocytes and macrophages.\u003cbr\u003e\nFunction: Activates STAT1, STAT3, Jak1, Tyk and is a component of cytokine receptor complexes specific for IL-22, IL-26, IL-28, and IL-29.\u003cbr\u003e\nLigand\/Receptor: IL-10\u003cbr\u003e\nCell Type: B cells, Macrophages, NK cells, T cells, Thymocytes\u003cbr\u003e\nBiology Area: Adaptive Immunity, Immunology, Signal Transduction\u003cbr\u003e\nMolecular Family: Cytokine\/Chemokine Receptors\u003cbr\u003e\nAntigen References: Donnelly RP, et al. 2004. J Leukoc Biol. 76(2):314-321. Koppelman B, et al. 1997. Immunity. (6): 861-871 Kotenko SV, et al. 1997. EMBO J. 16(19):5894-5903. Liu Y, et al. 1995. J Immunol. 152(4):1821-1829.\u003cbr\u003e\nGene ID: 3588\u003cbr\u003e\nUniProt: View information about CD210b on UniProt.org\u003cbr\u003e\nClone: S17009F\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Interleukin 10 receptor subunit beta, CRFB4, CRF2-4, D21S58, D21S66, CDW210B\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866230018217,"sku":"396807","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-396807","provider":"Iright","version":"1.0","type":"link"}