{"product_id":"biolegend-406509","title":"Biolegend, 406509, APC anti-mouse IgM Antibody, 100μg","description":"\u003cp\u003eIgM is the first immunoglobulin made by B cells in the immune response. Surface IgM is expressed on the majority of mature B cells.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Mouse Ig cocktail\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: 0.2 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: FC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nApplication Notes: The RMM-1 antibody reacts with both soluble and membrane immunoglobulin M in all tested mouse haplotypes (Igh-a and b). It does not react with other isotypes. Some formats of the RMM-1 antibody may be used as primary or secondary reagent for immunofluorescent staining or ELISA analysis.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Tertilt C, et al. 2009. Infect. Immun. 77:3044. (ELISA) PubMed\u003cbr\u003e\nProduct Citations: Ridenour D, et al. 2014. Development. 141:1095. PubMed Herrejon Chavez F, et al. 2023. Nat Commun. 14:2290. PubMed Leung G, et al. 2021. JCI Insight. 6:. PubMed Ryszawy D, et al. 2014. Carcinogenesis. 35:1920. PubMed Wang X, et al. 2016. PLoS Pathog. 12: 1005367. PubMed Schiller M, et al. 2021. Immunity. 54(5):1022-1036.e8. PubMed Sochalska M, et al. 2016. Oncogene. 10.1038\/onc.2016.362. PubMed Billi AC, et al. 2019. JCI Insight. 4:8. PubMed Yang Y, et al. 2021. Nat Commun. 12:525. PubMed Wong R, et al. 2020. Immunity. 53(5):1078-1094.e7. PubMed Shukla V, et al. 2020. Molecular Cell. 77(2):384-394.e4.. PubMed Reismann D, et al. 2017. Nat Commun.. 10.1038\/s41467-017-01538-9. PubMed Cheng Y, et al. 2019. Cell Rep. 28:1703. PubMed Germundson DL, et al. 2022. Front Allergy. 3:870513. PubMed Nick H, et al. 2012. Blood. 119:1370. PubMed Shibad V, et al. 2021. Front Immunol. 12:722451. PubMed Gomez S, et al. 2022. J Immunother Cancer. 10:. PubMed Hoyt T, et al. 2015. Infect Immun . 83:743. PubMed Iype J, et al. 2019. J Immunol. 202:1417. PubMed Scally S, et al. 2017. Nat Commun. . 10.1038\/s41467-017-01924-3. PubMed Schuler F, et al. 2017. Nat Commun. . 10.1038\/s41467-017-01850-4. PubMed Hirata T, et al. 2018. Nat Commun. 9:405. PubMed Lu X, et al. 2019. Cell Rep. 28:472. PubMed Yao C, et al. 2018. Autophagy. 1.854861111. PubMed Chen C, et al. 2020. Cell Rep. 2136:30. PubMed Strawbridge R, et al. 2016. Diabetes. 65: 2888 - 2899. PubMed Li K, et al. 2020. Nat Commun. 0.795138889. PubMed Pan J, et al. 2022. Front Immunol. 13:812924. PubMed Mao C, et al. 2020. Antib Ther. 0.234027778. PubMed Park SM et al. 2018. Cell stem cell. 24(1):153-165 . PubMed Jee D et al. 2018. Molecular cell. 69(2):265-278 . PubMed Gu Z, et al. 2021. Nat Genet. 53:672. PubMed\u003cbr\u003e\nRRID: AB_315059 (BioLegend Cat. No. 406509)\u003cbr\u003e\nStructure: Ig family\u003cbr\u003e\nDistribution: B cells\u003cbr\u003e\nFunction: B cell differentiation, humoral immune response; cross-linking surface IgM induces apoptosis\u003cbr\u003e\nCell Type: B cells\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nGene ID: 16019\u003cbr\u003e\nUniProt: View information about IgM on UniProt.org\u003cbr\u003e\nClone: RMM-1\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Immunoglobulin M\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866201313449,"sku":"406509","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-406509","provider":"Iright","version":"1.0","type":"link"}