{"product_id":"biolegend-427504","title":"Biolegend, 427504, Rapamycin, 1kit","description":"\u003cp\u003eRapamycin is an antifungal metabolite produced by Streptomyces hygroscopicus . Rapamycin is a potent and specific mTOR inhibitor. This allosteric inhibitor of mammalian mTORC1 induces autophagy and also acts as an immunosuppressant. mTORC1 is a central integrator of nutrient signaling pathways and stimulates cell growth and proliferation by activating anabolic processes inhibiting catabolic process such as autophagy.\u003cbr\u003e\n1kit\u003cbr\u003e\nFormulation: 1 vial of Rapamycin (10mg, lyophilized), 1 vial of DMSO\u003cbr\u003e\nPreparation: Solubility: DMSO: 18.28 mg\/mL (20 mM) Preparation of stock solution: Resuspend 10 mg of lyophilized Rapamycin in 546.9 µL of fresh DMSO to make a 20 mM stock solution\u003cbr\u003e\nStorage \u0026amp; Handling: Store lyophilized powder at -20°C. Protect from light. Once reconstituted, store aliquoted at -80°C. Use reconstituted material within 6 months to avoid loss of potency.\u003cbr\u003e\nApplication: Cell Culture - Verified\u003cbr\u003e\nRecommended Usage: Rapamycin was used for induction of Autophagy in a range from 1 to 40 µM. It is recommended that the reagent be titrated for each experiment to determine optimal performance.\u003cbr\u003e\nFunction: mTOR inhibitor, induced autophagy, immunosuppressant\u003cbr\u003e\nAntigen References: Ballou, et al. 2008. J Chem Biol. 1:27. Fleming, et al. 2011. Nat Chem Biol. 7:9. Galluzzi, et al. 2017. Nat Rev Drug Discov. 16:487.\u003cbr\u003e\nGene ID: NA\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Autophagy inducer, mTOR inhibitor\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866481348777,"sku":"427504","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-427504","provider":"Iright","version":"1.0","type":"link"}