{"product_id":"biolegend-511601","title":"Biolegend, 511601, Purified anti-human IL-1β Antibody, 50μg","description":"\u003cp\u003eIL-1 refers to two proteins, IL-1α and IL-1β which are the products of distinct genes, but which are recognized by the same cell surface receptors. IL-1β is a potent immuno-modulator which mediates a wide range of immune and inflammatory responses including the activation of B and T cells.\u003cbr\u003e\n50μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: ELISA Capture - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by ELISA assay. Purified H1b-27 is useful as the capture antibody in a sandwich ELISA when used in conjunction with the biotinylated Poly5174 (Cat. No. 517403) or H1b-98 antibody (Cat. No. 511703). For ELISA capture applications, a concentration range of 2-6 µg\/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Diray-Arce J, et al. 2023. Cell Rep Med. 4:101079. PubMed Huang C, et al. 2019. Cell Rep. 29:4525. PubMed Stras SF, et al. 2020. Developmental Cell. 51(3):357-373.e5.. PubMed Croden J, et al. 2021. PLoS One. 16:e0258208. PubMed Bando H, et al. 2019. Front Cell Infect Microbiol. 9:140. PubMed Watkins H, et al. 2017. Mol Ther. 10.1016\/j.ymthe.2017.01.010. PubMed Stensland ZC, et al. 2022. iScience. 25:103626. PubMed Lavin Y et al. 2017. Cell. 169(4):750-765 . PubMed\u003cbr\u003e\nRRID: AB_1236517 (BioLegend Cat. No. 511601) AB_1236518 (BioLegend Cat. No. 511602)\u003cbr\u003e\nStructure: Cytokine; 17.3 kD\u003cbr\u003e\nBioactivity: Stimulates T cells, B cells, proliferation\/activation of NK cells, fibroblasts, thymocytes, glioblastoma cells, astroglia, microglia\u003cbr\u003e\nCell Sources: Monocytes, tissue macrophages, Langerhans cells, dendritic cells, T and B cells, natural killer (NK) cells, large granular lymphocytes (LGL), vascular endothelium, smooth muscle, fibroblasts, thymic epithelia, astrocytes, microglia, glioma, keratinocytes,\u003cbr\u003e\nCell Targets: B cells, T cells, monocytes\u003cbr\u003e\nReceptors: Type I IL-1R (CDw121a), Type II IL-1R (CDw121b)\u003cbr\u003e\nBiology Area: Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: 1. Fitzgerald K, et al. Eds. 2001. The Cytokine FactsBook. Academic Press San Diego. 2. Bomford R, et al. Eds. 1989. Interleukin-1 inflammation and disease. Elsevier New York. 3. Brazel D, et al. 1991. Biotechnol. Ther. 2:241. 4. Dinarello C. 1996. Blood 87:2095.\u003cbr\u003e\nRegulation: Upregulated by TNF-α, IFN-α, IFN-β, IFN-γ, bacterial endotoxins, viruses, mitogens, antigens; downregulated by IL-6, lipoproteins, lipids, and α2-macroglobulin\u003cbr\u003e\nGene ID: 3553\u003cbr\u003e\nUniProt: View information about IL-1beta on UniProt.org\u003cbr\u003e\nClone: H1b-27\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Interleukin-1β, H1, OAF, Catabolin, IFNb-inducing factor(il-1b,il1b)\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866101076137,"sku":"511601","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-511601","provider":"Iright","version":"1.0","type":"link"}