{"product_id":"biolegend-600352","title":"Biolegend, 600352, Purified anti-Aquaporin-4 Antibody, 100μg","description":"\u003cp\u003eAquaporin-4 (AQP4) is a member of the water-selective channel family that is predominantly expressed in astrocytes in the central nervous system. AQP4 is a regulator of water homeostasis by exchanging water across the endfoot membranes in the brain. This protein is vital for maintaining the normal level of cerebrospinal fluid influx into the brain cortex, parenchyma, and perivascular space.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Partial recombinant human AQP4 protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: IHC-P - Quality tested ICC, IHC-F, WB, IP - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 5 - 10 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Ramadhanti J, et al. 2013. Monoclon Antib Immunogiagn Immunother. 32:270-276\u003cbr\u003e\nRRID: AB_2904437 (BioLegend Cat. No. 600351) AB_2904437 (BioLegend Cat. No. 600352)\u003cbr\u003e\nStructure: Aquaporin 4 is a 323 amino acid protein with a molecular mass of 35 kD.\u003cbr\u003e\nDistribution: Tissue distribution: astrocytes in CNS Cellular distribution: plasma membrane, endosome, and cytoskeleton\u003cbr\u003e\nFunction: AQP4 facilitates the transport of water across the blood-brain interface.\u003cbr\u003e\nCell Type: Astrocytes\u003cbr\u003e\nBiology Area: Cell Biology, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nAntigen References: Salman MM, et al. 2021. Nat Rev Neurosci. 22:650-651 Tang G and Yang GY. 2016. Int J Mol Sci. 17:1413 Jarius S and Wildemann B. 2013. Brain Pathol. 23:661-83\u003cbr\u003e\nGene ID: 361\u003cbr\u003e\nUniProt: View information about Aquaporin-4 on UniProt.org\u003cbr\u003e\nClone: E5206\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: MIWC, WCH4, AQP4\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46863066300585,"sku":"600352","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-600352","provider":"Iright","version":"1.0","type":"link"}