{"product_id":"biolegend-600951","title":"Biolegend, 600951, Purified anti-Thrombospondin 1 Antibody, 25μg","description":"\u003cp\u003eThrombospondin 1 (THBS1) is a member of the thrombospondin family, a group of matricellular proteins that comprise a part of the extracellular matrix. Originally discovered in platelets, THBS1 mediates cell-cell interactions interacting with numerous ligands including heparin, integrins, CD36, and CD47. Through this activity, THBS1 regulates cell adhesion, motility and growth. THBS1 has been implicated in the activity of various cancers, by mediating angiogenesis and tumor cell invasion, and also plays a role in heart disease, fibrosis, and eye health.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant N-terminal fragment of THBS1\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg\/mL. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2910473 (BioLegend Cat. No. 600951) AB_2910473 (BioLegend Cat. No. 600952)\u003cbr\u003e\nStructure: THBS1 is a 1,170 amino acid protein with a predicted molecular weight of 130 kD.\u003cbr\u003e\nDistribution: Secreted protein expressed by multiple cell types including platelets, smooth muscle cells, fibroblasts, and granulocytes\u003cbr\u003e\nFunction: TGF-β signaling, angiogenesis\u003cbr\u003e\nLigand\/Receptor: Heparin, HSPG, sulfatides, versican, calreticulin, integrins, MMPs, TGF-β, CD36, CD47, CD148\u003cbr\u003e\nCell Type: Endothelial cells\u003cbr\u003e\nBiology Area: Angiogenesis, Apoptosis\/Tumor Suppressors\/Cell Death, Cell Adhesion, Cell Motility\/Cytoskeleton\/Structure\u003cbr\u003e\nMolecular Family: Adhesion Molecules\u003cbr\u003e\nAntigen References: Zhang K, et al. 2020. Int J Mol Med. 45:1275-1293. Wang P, et al. 2020. Curr Pharm Des. 26:2116-2136.\u003cbr\u003e\nGene ID: 7057\u003cbr\u003e\nUniProt: View information about Thrombospondin 1 on UniProt.org\u003cbr\u003e\nClone: W20027B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Glycoprotein G, THBS-1\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866417877161,"sku":"600951","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-600951","provider":"Iright","version":"1.0","type":"link"}