{"product_id":"biolegend-607251","title":"Biolegend, 607251, Purified anti-MALT1 Antibody, 25μg","description":"\u003cp\u003eMALT1 is a ubiquitously expressed protease that is localized in the cytoplasm as a catalytically inactive BCL10-bound proenzyme. MALT1 acts downstream of oligomeric CARMA\/CARD-BCL10-MALT1 (CBM) complexes to regulate various functions in which MALT1 serves a dual purpose. Firstly, MALT1 is a scaffolding protein that plays an integral role in the regulation of the NF-κB and MAP kinase p38 pathways. In addition to serving as a scaffolding protein, MALT1 also possesses protease activity which promotes lymphocyte activation by cleavage of signaling proteins. Furthermore, MALT1 possesses a caspase-like domain with two conserved residues, cysteine 464 and histidine 415, which act as catalytic mechanisms in caspases and cysteine proteases ultimately contributing to inflammation, cell death, and cell proliferation.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant fragment of human MALT-1\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: IHC-P - Quality tested ICC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 5.0 - 10.0 µg\/mL is suggested. For immunocytochemistry, a concentration range of 1.25 - 5.0 μg\/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: For ICC, we recommend fixation with 4%PFA, followed by permeabilization with 0.5% Triton-X or 100% ice-cold methanol. We do not recommend methanol fixation. This antibody is not suitable for WB due to poor target selectivity.\u003cbr\u003e\nRRID: AB_2927965 (BioLegend Cat. No. 607251) AB_2927965 (BioLegend Cat. No. 607252)\u003cbr\u003e\nStructure: MALT1 is an 824 amino-acid protein with a predicted molecular weight of 92 kD.\u003cbr\u003e\nDistribution: MALT1 is ubiquitously expressed in the cytoplasm.\u003cbr\u003e\nFunction: Scaffolding protein, protease\u003cbr\u003e\nInteraction: MALT1 acts downstream of CARMA\/CARD-BCL10-MALT1 (CBM) complexes to regulate NF-kappa-B and MAP kinase p38 pathways.\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Biology, Cell Proliferation and Viability\u003cbr\u003e\nMolecular Family: Enzymes and Regulators, Proteases, Scaffold Proteins\u003cbr\u003e\nAntigen References: Beyaert R, et al. 2015. FEBS J. 282:3286-97. Thome M, et al. 2018. Front Immunol. 9:1927. Hailfinger S, et al. 2016. J Invest Dermatol. 136:788-79.\u003cbr\u003e\nGene ID: 10892\u003cbr\u003e\nUniProt: View information about MALT1 on UniProt.org\u003cbr\u003e\nClone: W20127A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: MALT1 Paracaspase, PCASP1, MLT, Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1, Mucosa Associated Lymphoid Tissue Lymphoma Translocation Gene 1, MALT1 Protease, MALT Lymphoma-Associated Translocation, Caspase-Like Protein, MLT1\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866422300841,"sku":"607251","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-607251","provider":"Iright","version":"1.0","type":"link"}