{"product_id":"biolegend-610608","title":"Biolegend, 610608, APC anti-MEK1 Phospho (Ser298) Antibody, 100tests","description":"\u003cp\u003eMEK1 and MEK2 (Map\/Erk Kinase) are serine\/threonine kinases in the MAPK\/ERK signaling axis that play a critical role in cellular proliferation, differentiation, and migration. Phosphorylation at MEK1 (Ser298) by PAK1 enhances the ability of upstream Raf kinases to phosphorylate regulatory serines (Ser218 and Ser222) in the activation loop, thereby stimulating kinase activity.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human MEK1 peptide phosphorylated at Ser298. Complete Freund’s adjuvant.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nExcitation Laser: Red Laser (633 nm)\u003cbr\u003e\nRRID: AB_2888737 (BioLegend Cat. No. 610607) AB_2888737 (BioLegend Cat. No. 610608)\u003cbr\u003e\nStructure: MEK1 is a 393 amino acid protein with a predicted molecular weight of 43 kD\u003cbr\u003e\nDistribution: Ubiquitously expressed\/cytosolic\u003cbr\u003e\nBiology Area: Cell Biology, Cell Proliferation and Viability, Signal Transduction\u003cbr\u003e\nMolecular Family: Phospho-Proteins, Protein Kinases\/Phosphatase\u003cbr\u003e\nAntigen References: Song C, et al. 2017. Sci Rep. 7:46833. Jeong DE, et al. 2017. EMBO J. 36:1046. Kyriakakis E, et al. 2017. Cell Signal. 35:163. Narbonne P, et al. PLoS Genet. 13:e1006738. Wu H, et al. 2013. PLoS One. 8:e83737. Wang Z, et al. 2010. Oncogene. 29:3362. Moniz S, et al. 2007. Oncogene. 26:6071. Park ER, et al. 2007. Cell Signal. 7:1488.\u003cbr\u003e\nGene ID: 5604\u003cbr\u003e\nUniProt: View information about MEK1 Phospho Ser298 on UniProt.org\u003cbr\u003e\nClone: A16117B\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: MEK1, MAP2K1, CFC3, MKK1, MAPKK1, PRKMK1\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864401170601,"sku":"610608","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-610608","provider":"Iright","version":"1.0","type":"link"}