{"product_id":"biolegend-615651","title":"Biolegend, 615651, Purified anti-Aldolase C Antibody, 25μg","description":"\u003cp\u003eAldolase C is one of the three aldolase isozymes and plays a key role in ATP biosynthesis. It participates in glycolysis and gluconeogenesis by catalyzing the conversion of fructose-1-6-biphosphate to glyceraldehyde-3-phosphate, or glyceraldehyde, and di-hydroxy-acetone-phosphate. In addition, it is part of the stress-response pathway induced by hypoxia. It has been found that Aldolase C is upregulated in the brains of schizophrenia patients. Moreover, inactivation of Aldolase C by oxidation has been reported in mild cognitive impairment (MCI) and Alzheimer’s disease (AD).\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human Aldolase C\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested IHC-P, ICC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg\/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0 - 5.0 µg\/mL is suggested. For immunocytochemistry, a concentration range of 2.5 - 5.0 μg\/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2941622 (BioLegend Cat. No. 615651) AB_2941622 (BioLegend Cat. No. 615652)\u003cbr\u003e\nStructure: Aldolase C is a 364 amino acid protein with an expected molecular weight of 39 kD.It is a member of the three aldolase isozymes. Aldose C shares 68% identity with Aldolase B and 78% with Aldolase A. The catalytic site is highly conserved in all three isoforms.\u003cbr\u003e\nDistribution: Although Aldolase C is widely expressed, it is predominantly expressed in the hippocampus, Purkinje cells, neurons of the brain, and smooth muscle.\u003cbr\u003e\nFunction: Glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively.\u003cbr\u003e\nBiology Area: Cell Biology, Neurodegeneration, Neuroscience\u003cbr\u003e\nMolecular Family: Enzymes and Regulators\u003cbr\u003e\nAntigen References: Chen X, et al. 2022. Nature. 605:722-727. Chang YC, et al. 2018. Trends Endocrinol Metab. 28:549-559. Juszczak GR, et al. 2017. Prog Neuropsychopharmacol Biol Psychiatry. 82:136. Lai GE, et al. 2022. Gland Surg. 11:826-836.\u003cbr\u003e\nGene ID: 230\u003cbr\u003e\nUniProt: View information about Aldolase C on UniProt.org\u003cbr\u003e\nClone: A18070A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Aldolase, fructose-biphosphate C, ALDC, Aldolase C, Aldolase 3, Fructoaldolase C\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866060542121,"sku":"615651","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-615651","provider":"Iright","version":"1.0","type":"link"}