{"product_id":"biolegend-616351","title":"Biolegend, 616351, Purified anti-Glycodelin Antibody, 25μg","description":"\u003cp\u003eGlycodelin, also known as progesterone-associated endometrial protein (PAEP), belongs to the lipocalin family and exists in four glycoforms. The glycodelin isoforms are primarily expressed in different reproductive tissues, such as glycodelin-S in male seminal vesicles, glycodelin-A (GdA) in the endometrium, glycodelin-F (GdF) in fallopian tubes\/follicular fluid, and glycodelin-C (GdC) in cumulus cells. Glycodelin isoforms are involved in reproductive processes such as implantation, fertilization, and pregnancy maintenance. GdA plays a crucial role in differentiating natural killer (NK) cells to decidual NK cells and modulating the NK cells to prevent maternal immune rejection during embryo development. At the feto-maternal interface, GdA inhibits the proliferation of T-cells and induces their apoptosis through Th receptors. GdC is converted from GdA and GdF through glycosylation modification and facilitates sperm-zona pellucida binding. Recently, abnormal glycodelin expression has been observed in various cancers, including ovarian, breast, colon, and lung cancers. Mice xenograft models have revealed that glycodelin plays a role in tumor proliferation and invasion.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant fragment of human glycodelin\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg\/mL. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This product is not recommended for use in immunohistochemistry.\u003cbr\u003e\nRRID: AB_2941624 (BioLegend Cat. No. 616351) AB_2941624 (BioLegend Cat. No. 616352)\u003cbr\u003e\nStructure: Forms four glycoforms, glycodelin-S, -A, -F and -C; homodimer\u003cbr\u003e\nDistribution: Expressed in and secreted by reproductive tissues\u003cbr\u003e\nFunction: Participates in reproductive processes, including implantation, fertilization, and pregnancy maintenance\u003cbr\u003e\nInteraction: A2M, SIGLEC6\u003cbr\u003e\nBiology Area: Immunology\u003cbr\u003e\nAntigen References: Seppala M, et al. 2007. Hum Reprod Update. 3:275-87. Ren S, et al. 2010. J Cell Mol Med. 4:1432-42. Lee C-L, et al. 2011. J Repord Immunol. 90:29-34. Cui J, et al. 2017. Front Immunol. 8:1685. Lee C-L, et al. 2019. Hum Reprod. 34:689-701.\u003cbr\u003e\nGene ID: 5047\u003cbr\u003e\nUniProt: View information about Glycodelin on UniProt.org\u003cbr\u003e\nClone: A16006H\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Placental protein 14, PP14, Progestagen-associated endometrial protein, Progesterone-associated endometrial protein, PAEP, Zona-binding inhibitory factor-1. ZIF-1, Pregnancy-associated endometrial alpha-2 globulin, PAEG, PEG\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864391602345,"sku":"616351","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-616351","provider":"Iright","version":"1.0","type":"link"}