{"product_id":"biolegend-620752","title":"Biolegend, 620752, Purified anti-Sun2 Antibody, 100μg","description":"\u003cp\u003eSun2 is a transmembrane protein that localizes to the inner nuclear membrane and interacts with other nuclear proteins to form the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex. This complex bridges the nuclear envelope, connecting the nuclear lamina to the cytoskeleton, thereby providing mechanical support and stability to the nucleus. Sun2 also plays a vital role in nuclear migration, chromosome organization, and gene regulation. Additionally, Sun2 is involved in maintaining nuclear envelope integrity during cell division and DNA repair, and has been suggested to act as a tumor suppressor by protecting against cancer-inducing DNA damage. In lung cancer, Sun2 has been shown to inhibit the Warburg effect via Glut1 and LDHA.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Residues 1-121 of human SUN2 fused to GST\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested ICC, IHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg\/mL. For immunocytochemistry, a concentration range of 1.0 - 10.0 μg\/mL is recommended. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0 - 10.0 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: For IHC-P, antigen retrieval using Citrate buffer, pH 6.0 (Cat. No. 420901) is recommended. For ICC, we recommend fixation\/permeabilization with 100% ice-cold methanol for 10 minutes. Other fixation\/permeabilization methods have not been tested.\u003cbr\u003e\nRRID: AB_3097218 (BioLegend Cat. No. 620751) AB_3097218 (BioLegend Cat. No. 620752)\u003cbr\u003e\nStructure: Sun2 is a 717 amino acid protein with a predicted molecular weight of 80.3 kD.\u003cbr\u003e\nDistribution: Nuclear membrane, ubiquitously expressed in all cell types\u003cbr\u003e\nFunction: Structural protein\u003cbr\u003e\nInteraction: Sun1, Nesprin 1g, Nesprin 1α\u003cbr\u003e\nBiology Area: Cell Motility\/Cytoskeleton\/Structure, Cell Structure\u003cbr\u003e\nMolecular Family: Nuclear Markers\u003cbr\u003e\nAntigen References: Stroud M, et al. 2014. Circ. Res. 114538-48. Chen X, et al. 2019. Oncol Lett. 17:01-1408. Meinke P, et al.2011. Biochem Soc Trans. 39:1693-7. Lv X, et al. 2016. Sci Rep. 5:17940.\u003cbr\u003e\nGene ID: 25777\u003cbr\u003e\nUniProt: View information about Sun2 on UniProt.org\u003cbr\u003e\nClone: 3.1E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Sad1 and UNC84 domain containing 2, UNC84B,SUN Domain-Containing Protein 2, Rab5-Interacting Protein, FRIGG, Protein unc-84 homolog B, Rab5IP, Sad1\/unc-84 protein-like 2\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862332231849,"sku":"620752","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-620752","provider":"Iright","version":"1.0","type":"link"}