{"product_id":"biolegend-621551","title":"Biolegend, 621551, Purified anti-YY1 Antibody, 25μg","description":"\u003cp\u003eYin Yang 1 (YY1), is a ubiquitously distributed transcription factor that plays a pivotal role in regulating gene expression and coordinating various cellular processes. By interacting with other transcription factors, co-regulators, and epigenetic modifiers, YY1 can modulate gene expression to control diverse biological processes, including cell proliferation, differentiation, apoptosis, and development. Based on its interactions with other proteins such as MYC, YY1 can function as a transcriptional activator or repressor. Furthermore, YY1 is involved in maintaining genomic stability and has been implicated in DNA repair mechanisms. Its ability to interact with a wide range of regulatory elements and its context-dependent transcriptional activities make YY1 an essential factor in orchestrating intricate gene regulatory networks within the cell, and a potential target for cancer therapies.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant full-length human YY1 expressed in E.coli\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested IHC-P - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg\/mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0 - 10.0 µg\/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone is not recommended for ICC application. For IHC-P antigen retrieval with either Tris-EDTA, pH 6.0, or sodium citrate, pH 9.0 (e.g. Cat. No. 420901) is recommended.\u003cbr\u003e\nRRID: AB_3083409 (BioLegend Cat. No. 621551) AB_3083409 (BioLegend Cat. No. 621552)\u003cbr\u003e\nStructure: YY1 is a 414 amino acid protein with a predicted molecular weight of 44.7 kD.\u003cbr\u003e\nDistribution: Ubiquitous, Nuclear\u003cbr\u003e\nFunction: Transcription factor\u003cbr\u003e\nInteraction: ATF6, EP300, FKBP3, HDAC3, HDAC2, Myc, NOTCH1, RYBP, SAP30, Yaf2\u003cbr\u003e\nBiology Area: Transcription Factors\u003cbr\u003e\nMolecular Family: Nuclear Markers\u003cbr\u003e\nAntigen References: Weintraub AS, et al. 2017. Cell. 171:1573-1588. Kachigian LM. 2018. Int J Cancer. 143:460-465. Chen F. et al. 2017. Crit Rev Oncog. 22:131-141. Sarvagalla S, et al .2019. Front Oncol. 9:1230.\u003cbr\u003e\nGene ID: 7528\u003cbr\u003e\nUniProt: View information about YY1 on UniProt.org\u003cbr\u003e\nClone: W21112E\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Yin Yang 1, Transcriptional repressor protein YY1, Delta transcription factor, INO80 complex subunit S, NF-E1\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866430099625,"sku":"621551","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-621551","provider":"Iright","version":"1.0","type":"link"}