{"product_id":"biolegend-628153","title":"Biolegend, 628153, Biotin anti-human CD26 (DPP4) Antibody, 50μg","description":"\u003cp\u003eDipeptidyl peptidase IV (DPP4) is a multifunctional type II transmembrane serine peptidase. It is also known as a cell surface glycoprotein receptor, CD26, involved in the co-stimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. It acts as a positive regulator of T-cell co-activation, by binding at least ADA, CAV1, IGF2R, and PTPRC. DPP4 is widely expressed in many specialized cell types and has distinct functions independently of its form, anchored to the membrane or in soluble form. The soluble form of DPP4 appears to be derived primarily from endothelial cells, epithelial cells, and leukocytes. It is upregulated in proinflammatory states including obesity, type-2 diabetes mellitus, and atherosclerosis. DPP4 is a serine aminopeptidase that cleaves preferentially Xaa–Pro dipeptides from oligopeptides with typical length of 30 amino acid, but tolerates other small residues at P1-position. Its biological substrates include many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Thus, it regulates various physiological processes by cleaving peptides in the circulation on the cell surface. It has been discovered that DPP4 may be a receptor for receptor binding domain (RBD) of spike entry glycoprotein in Middle East respiratory syndrome coronavirus (MERS-CoV).\u003cbr\u003e\n50μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human Recombinant DPP4 Protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.\u003cbr\u003e\nApplication: Direct ELISA - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Direct ELISA. The optimal concentration of this reagent for the specific application and the experiment design should be established by the end-user.\u003cbr\u003e\nAdditional Product Notes: This product is intended for sandwich-based immunoassay development on various assay platforms requiring antibody pairs. This antibody (clone 1-10) could function as a detection antibody when paired with purified anti-human CD26 (DPP4) (Cat. No. 628156) (clone 5-109) as the capture antibody and using Recombinant Human DPP4 (carrier-free) protein (Cat. Nos. 764102, 764104, and 764106) as the assay standard.\u003cbr\u003e\nRRID: AB_3106020 (BioLegend Cat. No. 628153)\u003cbr\u003e\nDistribution: High expression in RPTEC\/TERT1, BJ-hTERT, and ASC-TERT1 cell line; moderate expression in PC-3 and Hep G2 cell line\u003cbr\u003e\nInteraction: T-Cell, lymphocyte\u003cbr\u003e\nLigand\/Receptor: Adenosin deaminase (ADA), RANTES, stromal cell-derived factor (SDF)-1α, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1)\u003cbr\u003e\nCell Type: Embryonic Stem Cells\u003cbr\u003e\nBiology Area: Angiogenesis, Cell Biology, Stem Cells\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines, Growth Factors\u003cbr\u003e\nAntigen References: Metzemaekers M, et al. 2016. Front in Immunology. 7:483. Song W, et al.2014. Virology. 473:49-53. Ohnuma K, et al 2007. J Biol Chem. 282:10117-10131. Engel M, et al. 2003. PNAS USA. 100:5063. Morimoto C, et al. 1989. J Immunol. 143:3430-9.\u003cbr\u003e\nGene ID: 1803\u003cbr\u003e\nUniProt: View information about CD26 on UniProt.org\u003cbr\u003e\nClone: 1-10\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CD26, Adenosine deaminase binding protein (ADABP), Adenosine deaminase complex\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46860766118057,"sku":"628153","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-628153","provider":"Iright","version":"1.0","type":"link"}