{"product_id":"biolegend-631453","title":"Biolegend, 631453, Biotin anti-human PLAUR (uPAR) Antibody, 50μg","description":"\u003cp\u003ePLAUR (plasminogen activator urokinase receptor), also known as urokinase plasminogen activator-receptor (uPAR), is part of the plasminogen activation system, which is involved in tissue reorganization, cell migration, cell cycle regulation, and cell adhesion. PLAUR was originally identified as a saturable binding site for urokinase on the cell surface, and thus, restricting plasminogen activation to the immediate vicinity of the cell membrane. Due to lack of transmembrane or cytoplasmic domains, PLAUR may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its C-terminus. A soluble form of PLAUR has been identified. The membrane-bound PLAUR is expressed on granulocytes, monocytes\/macrophages, dendritic cells, fibroblasts, endothelial cells, and keratinocytes. This molecule plays a role in cell adhesion and chemotaxis through binding to β1, β2, and β3 integrins. Recently, it was found that soluble PLAUR is increased in plasma of patients with active lupus nephritis, suggesting an association with pathological features of the disease. In addition, soluble PLAUR has been linked as a causative factor and also a biomarker of several diseases including tumor metastasis, focal and segmental glomerulosclerosis, hepatocellular carcinoma, and coronary artery disease.\u003cbr\u003e\n50μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human Recombinant PLAUR (uPAR) Protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with biotin under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.\u003cbr\u003e\nApplication: Direct ELISA - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Direct ELISA. The optimal concentration of this reagent for the specific application and the experiment design should be established by the end-user.\u003cbr\u003e\nAdditional Product Notes: This product is intended for sandwich-based immunoassay development on various assay platforms requiring antibody pairs. This antibody (clone A20095T) could function as a detection antibody when paired with purified anti-human PLAUR (uPAR) (Cat. No. 632152) (clone A20095I) as the capture antibody and using Recombinant Human PLAUR (uPAR) (carrier-free) protein (Cat. Nos. 559702, 559704, and 559706) protein as the assay standard.\u003cbr\u003e\nRRID: AB_3675170 (BioLegend Cat. No. 631453)\u003cbr\u003e\nStructure: Monomer\u003cbr\u003e\nDistribution: Granulocytes, monocytes\/macrophages, dendritic cells, fibroblasts, endothelial cells, keratinocytes, and activated T cells\u003cbr\u003e\nFunction: Convert plasminogen to plasmin, cell adhesion, and chemotaxis\u003cbr\u003e\nLigand\/Receptor: uPA; LRP1 (CD91)\u003cbr\u003e\nCell Type: Embryonic Stem Cells\u003cbr\u003e\nBiology Area: Angiogenesis, Cell Biology, Stem Cells\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines, Growth Factors\u003cbr\u003e\nAntigen References: Llinas P, et al. 2005. EMBO J. 24:1655-63. Beaufort N, et al. 2004. J Immunol. 172:540-9. Tarui T, et al. 2001. J Biol Chem. 276:3983-90. Qin DD, et al. 2014. Lupus. 24:546-57. Thuno M, et al. 2009. Dis Markers. 27:157-72. Alfano D, et al. 2009. Front Biosci. 14:3782-94. Spinale JM, et al. 2014. Kidney Int. 87:564-74. Chounta A, et al. 2014. Liver Int. 35:601-7. Harskamp RE and Roe MT. 2014. J Am Heart Assoc. 3:e001431.\u003cbr\u003e\nGene ID: 5329\u003cbr\u003e\nUniProt: View information about PLAUR on UniProt.org\u003cbr\u003e\nClone: A20095T\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: CD87, MC3, Plasminogen activator urokinase receptor, uPAR, URKR\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003cbr\u003e\nQ: How many biotin molecules are per antibody structure?\u003cbr\u003e\nA: We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866070667433,"sku":"631453","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-631453","provider":"Iright","version":"1.0","type":"link"}