{"product_id":"biolegend-644901","title":"Biolegend, 644901, Purified anti-RORγ Antibody, 25μg","description":"\u003cp\u003eRORγ (Retinoid-related orphan receptor gamma) belongs to the nuclear hormone receptor family, NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. RORγ has two isoforms: γ1 and γ2 (also referred to as RORγt). The RORγt differs from the RORγ1 isoform in that it lacks the amino terminus of RORγ1. RORγ1 contains 516 amino acids and RORγt contains 495 amino acids. RORγ1 has a molecular weight of approximately 58 kD. RORγ1 is highly expressed in thymus, kidney, liver, muscle, and brown fat but not in white fat tissue. RORγt is specifically expressed in only two cell populations, DP thymocytes and lymphoid tissue inducers (LTi). RORγ plays a critical role in control apoptosis during thymopoiesis and T cell homeostasis. RORγ is to regulate TCRα repertoire by virtue of its positive regulatory role on Bcl-x expression. RORγ is essential for lymph nodes and Peyers patches development.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nReported Reactivity: Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Human RORγ-GST recombinant protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution: 1 to 4 µg\/ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This product weakly reacts with Mouse.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Klemann C, et al. 2009. Am J Pathol. 174:2234. PubMed\u003cbr\u003e\nProduct Citations: Hilt ZT, et al. 2019. Aging (Albany NY). 11955:11. PubMed Klemann C, et al. 2009. Am J Pathol. 174:2234. PubMed\u003cbr\u003e\nRRID: AB_1595502 (BioLegend Cat. No. 644902)\u003cbr\u003e\nStructure: Belongs to the nuclear hormone receptor family, NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. RORγ has two isoforms: γ1 and γ2 (also referred to as RORγt). The RORγt differs from the RORγ1 isoform in th\u003cbr\u003e\nDistribution: Th17 cells\u003cbr\u003e\nFunction: RORγt is essential for lymph nodes and Peyer's patches development. RORγt plays a critical role in control apoptosis during thymopoiesis and T cell homeostasis.\u003cbr\u003e\nCell Type: Th17\u003cbr\u003e\nBiology Area: Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: Nuclear Markers\u003cbr\u003e\nAntigen References: 1. Medvedev A, et al. 1997. Genomics 46:93. 2. He YW, et al. 1998. Immunity 9:797. 3. Eberl G, et al. 2004. Nat. Immunol. 5:64.\u003cbr\u003e\nGene ID: 19885\u003cbr\u003e\nUniProt: View information about RORgamma on UniProt.org\u003cbr\u003e\nClone: 4F3-3C8-2B7\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: RORc, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma\u003cbr\u003e\nIsotype: Mouse IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862415724713,"sku":"644901","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-644901","provider":"Iright","version":"1.0","type":"link"}