{"product_id":"biolegend-648880","title":"Biolegend, 648880, Purified anti-MOG Antibody, 25μg","description":"\u003cp\u003eMyelin oligodendrocyte glycoprotein (MOG) is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. This heavily N-glycosylated protein features a single extracellular immunoglobulin-like domain, a transmembrane region, and a short intracellular tail. MOG is expressed on the surface of oligodendrocytes in the outermost layer of myelin and is highly conserved across species. MOG plays a critical role in the completion and maintenance of the myelin sheath, possibly acting as a cell adhesion molecule that contributes to myelin integrity and immune regulation. MOG is notably implicated in a group of autoimmune demyelinating disorders collectively known as MOG antibody-associated disease (MOGAD). In these conditions, the immune system produces antibodies targeting MOG, leading to inflammation and damage in the optic nerves, spinal cord, and brain.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse, Rat\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human MOG protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: IHC-P - Quality tested ICC, WB, ICFC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 10.0 µg\/mL is suggested. For immunocytochemistry, a concentration range of 1.25 - 10.0 μg\/mL is recommended. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg\/mL. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nAdditional Product Notes: For use of this antibody in intracellular flow cytometry (ICFC), we recommend fixation and permeabilization using Cyto-Fast™ Fix-Perm Buffer set (Cat. No. 426803). Similar results were also obtained using True-Nuclear™ Transcription Factor Buffer set (Cat. No. 424401) or True-Phos™ Perm Buffer (Cat. No. 425401). For use of this antibody in immunohistochemistry on formalin-fixed paraffin-embedded tissues (IHC-P), we recommend antigen retrieval using either Citrate Buffer (Cat. No. 420902), or Tris-EDTA pH 9.0 Antigen Retrieval Buffer (Cat. No. 422704).\u003cbr\u003e\nRRID: AB_3720623 (BioLegend Cat. No. 648880) AB_3720623 (BioLegend Cat. No. 648881)\u003cbr\u003e\nStructure: MOG consists of 247 amino acids and has a molecular weight of approximately 28.2 kDa\u003cbr\u003e\nInteraction: • MOG acts as a receptor for rubella virus E2 Glycoprotein • ARL6IP5\u003cbr\u003e\nCell Type: Oligodendrocytes\u003cbr\u003e\nBiology Area: Cell Biology, Cell Structure, Immunology, Neurodegeneration, Neuroinflammation, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nAntigen References: Salama S, et al. 2019. Mult Scler. 25(11):1427. Moseley CE, et al. 2024. Neurol Neuroimmunol Neuroinflamm. 11(5):e200275. Wynford TR, et al. 2019. J Neurol. 266(5):1280.\u003cbr\u003e\nGene ID: 4340\u003cbr\u003e\nUniProt: View information about MOG on UniProt.org\u003cbr\u003e\nClone: A24108A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Myelin Oligodendrocyte Glycoprotein, MOGIG2, BTN6, BTNL11, NRCLP7\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866079350953,"sku":"648880","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-648880","provider":"Iright","version":"1.0","type":"link"}