{"product_id":"biolegend-657403","title":"Biolegend, 657403, Alexa Fluor® 488 anti-Tubulin Beta 3 (TUBB3) Antibody, 25μg","description":"\u003cp\u003eTubulin is the main component of microtubules. In adults, tubulin beta 3 (TUBB3) is primarily expressed in neurons and is commonly used as a neuronal marker. It plays an important role in neuronal cell proliferation and differentiation. Mutations in this gene cause congenital fibrosis of the type 3 extraocular muscles. Tubulin beta 3 (TUBB3) is also found in a wide range of tumors. Studies indicate that it is a predictive and prognostic marker in various tumors.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Mouse, Rat, Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Fusion protein\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested IHC-F, 3D IHC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. For immunohistochemical staining on frozen tissue sections, the suggested use is 1.25 - 5.0 µg\/mL. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nApplication Notes: Additional reported application (for relevant formats) include: spatial biology (IBEX)1,2.\u003cbr\u003e\nApplication References(PubMed link indicates BioLegend citation): Radtke AJ, et al. 2020. Proc Natl Acad Sci U S A. 117:33455-65. (SB) PubMed Radtke AJ, et al. 2022. Nat Protoc. 17:378-401. (SB) PubMed\u003cbr\u003e\nProduct Citations: Metzner K, et al. 2022. Front Cell Dev Biol. 10:965382. PubMed Yu C, et al. 2022. Invest Ophthalmol Vis Sci. 63:1. PubMed Gao X, et al. 2021. Nature. 589:591. PubMed Zhang J, et al. 2020. J Cell Mol Med. 24:4547. PubMed\u003cbr\u003e\nRRID: AB_2562669 (BioLegend Cat. No. 657403) AB_2562670 (BioLegend Cat. No. 657404)\u003cbr\u003e\nStructure: 450 amino acids with predicted molecular weight of 50 kD\u003cbr\u003e\nDistribution: Cytosol\u003cbr\u003e\nFunction: Plays important roles in neuronal cell proliferation and differentiation\u003cbr\u003e\nInteraction: Alpha tubulin, kinesin and dynein\u003cbr\u003e\nCell Type: Mature Neurons\u003cbr\u003e\nBiology Area: Cell Biology, Cell Cycle\/DNA Replication, Cell Motility\/Cytoskeleton\/Structure, Immunology, Neuroscience, Neuroscience Cell Markers\u003cbr\u003e\nMolecular Family: Microtubules\u003cbr\u003e\nAntigen References: 1. Katsetos CD, et al. 2003. J. Child Neurol. 18:851. 2. Mobarakeh ZT, et al. 2012. Cell Biol. Int. Rep. (2010) 19:e00015. 3. Locher H, et al. 2013. Differentiation. 85:173. 4. Karki R, et al. 2013. Expert Opin. Ther. Targets. 17:461. 5. Mariani M, et al. 2011. Curr. Mol. Med. 11:726. 6. Koh Y, et al. 2009. Ann. Oncol. 20:1414.\u003cbr\u003e\nGene ID: 10381\u003cbr\u003e\nUniProt: View information about Tubulin beta-3 on UniProt.org\u003cbr\u003e\nClone: AA10\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: β-3 Tubulin, Neuronal class III beta-tubulin, β3-tub\u003cbr\u003e\nIsotype: Mouse IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46862526447785,"sku":"657403","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-657403","provider":"Iright","version":"1.0","type":"link"}