{"product_id":"biolegend-659608","title":"Biolegend, 659608, Alexa Fluor® 488 anti-human IL-31 Antibody, 100tests","description":"\u003cp\u003eIL-31, produced mainly by activated CD4 + T cells, is a newly discovered helical cytokine belonging to the gp130\/IL6 cytokine family. IL-31 is closely related in structure to IL-6, IL-11, and IL-27. Binding of IL-31 to its receptor activates JAK\/STAT, PI3K\/AKT, and MAPK pathways. IL-31 acts on a broad range of immune and non-immune cells and thus possesses potential pleiotropic physiological functions, such as regulating hematopoiesis and immune response. Human IL-31 is also involved in inflammatory bowel disease, airway hypersensitivity, and dermatitis.\u003cbr\u003e\n100tests\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Full length human IL-31 recombinant protein expressed in E. coli.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.\u003cbr\u003e\nConcentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.\u003cbr\u003e\nApplication: ICFC - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood. * Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm.Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses\u003cbr\u003e\nExcitation Laser: Blue Laser (488 nm)\u003cbr\u003e\nProduct Citations: Bai Z, et al. 2024. Nature. 702:634. PubMed\u003cbr\u003e\nRRID: AB_2616660 (BioLegend Cat. No. 659607) AB_2616661 (BioLegend Cat. No. 659608)\u003cbr\u003e\nStructure: 161 aa with with a putative 23 aa signal peptide that is cleaved to generate a 138 aa mature protein.\u003cbr\u003e\nDistribution: Secreted by activated CD4 T cells.\u003cbr\u003e\nFunction: IL-31 belongs to the IL-6 family of cytokines and plays a role in skin inflammation.\u003cbr\u003e\nLigand\/Receptor: Binds to IL-31 receptor complex that consists of two receptor subunits, IL31RA and OSMR.\u003cbr\u003e\nCell Type: Eosinophils, T cells\u003cbr\u003e\nBiology Area: Cell Biology, Immunology\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: 1. McCandless EE, et al. 2014. Vet. Immunol. Immunopathol. 157:42. 2. Arai I, et al. 2013. Exp. Dermatol. 22:669. 3. Dai X, et al. 2013. PLoS One. 8:e67666. 4. Stott B, et al. 2013. J. Allergy Clin. Immunol. 132:446. 5. Hartmann K, et al. 2013. J. Allergy Clin. Immunol. 132:232. 6. Baron JM and Lüscher B. 2012. Acta. Derm. Venereol. 92:5.\u003cbr\u003e\nGene ID: 386653\u003cbr\u003e\nUniProt: View information about IL-31 on UniProt.org\u003cbr\u003e\nClone: 1D10B31\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Interleukin-31\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46864361619625,"sku":"659608","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-659608","provider":"Iright","version":"1.0","type":"link"}