{"product_id":"biolegend-661802","title":"Biolegend, 661802, Purified anti-Hsp90α\/β Antibody, 100μg","description":"\u003cp\u003eHsp90 is one of the most abundant molecular chaperones. It modulates the stability and transport of a diverse set of critical factors, including regulatory, metabolic, organizational, and signaling proteins. There are two major isoforms: α and β. In humans, the Hsp90β isoform is constitutively expressed, whereas the Hsp90α isoform is expressed under stress conditions. The Hsp90 dimer acts in concert with other chaperones and is regulated by a number of co-chaperones\/accessory proteins. Upregulation of Hsp90 is associated with tumor progression, invasion and formation of metastases, and development of drug resistance. Therefore Hsp90 has emerged as an important target for cancer treatment.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human, Mouse\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Amino acids 291-304 of human HSP90α and β\u003cbr\u003e\nFormulation: Aqueous solution containing 0.095% sodium azide\u003cbr\u003e\nPreparation: Antibody was purified by ammonium sulphate precipitation\u003cbr\u003e\nConcentration: 0.5 mg\/mL\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested ICC - Verified ELISA - Reported in the literature, not verified in house\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.125 - 1.0 µg per mL. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Matsusaka T. 1996. Jpn. J. Oral. Biol. 38:633. Nemoto T, et al. 1997. J. Biol. Chem. 272:26179. (ELISA) Nemoto T, et al. 1997. Biochem. Mol. Biol. Int. 42:881.\u003cbr\u003e\nProduct Citations: Zubiaga L, et al. 2023. iScience. 26:106057. PubMed\u003cbr\u003e\nRRID: AB_2564179 (BioLegend Cat. No. 661802)\u003cbr\u003e\nStructure: Hsp90α: 732 amino acids, predicted molecular weight of approximately 85 kD. Hsp90ß: 724 amino acids, predicted molecular weight of approximately 83 kD.\u003cbr\u003e\nDistribution: Cytoplasmic and nuclear.\u003cbr\u003e\nFunction: Hsp90 is one of the most abundant molecular chaperones. It modulates the stability and transport of a diverse set of critical factors, including regulatory, metabolic, organizational, and signaling proteins.\u003cbr\u003e\nInteraction: NR3C1, FKBP4, FKBP5, PPID, PPP5C, STIP1, AHSA1, FNIP1, HSF1, SMYD3, TOM34, TERT, PTGES3, CHORDC1, DNAJC7, STUB1, UBE2N, PPP5C, PPP5C, p53\/TP53 and CDK6\u003cbr\u003e\nBiology Area: Cell Biology, Cell Cycle\/DNA Replication, DNA Repair\/Replication, Neurodegeneration, Neuroinflammation, Neuroscience, Protein Trafficking and Clearance, Signal Transduction\u003cbr\u003e\nAntigen References: Barrott JJ, et al. 2013. FEBS J. 280:1381. Gorska M, et al. 2012. Front. Biosci. (Landmark Ed) 17:2269. Barginear MF, et al. 2008. Curr. Cancer Drug Targets. 8:522. Arya R, et al. 2007. J. Biosci. 32:595. Neckers L, et al. 2003. Curr. Opin. Oncol. 15:419. Nemoto T, et al. 1997. J. Biol. Chem. 272: 26179.\u003cbr\u003e\nGene ID: 33203326\u003cbr\u003e\nUniProt: View information about Hsp90alpha\/beta on UniProt.org\u003cbr\u003e\nClone: K3720A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Heat Shock Protein 90kD Alpha (Cytosolic), Heat Shock 90 kD Protein 1, Beta, Class\u003cbr\u003e\nIsotype: Mouse IgG1\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866459099305,"sku":"661802","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-661802","provider":"Iright","version":"1.0","type":"link"}