{"product_id":"biolegend-661902","title":"Biolegend, 661902, Purified anti-NGAL (Lipocalin-2) Antibody, 100μg","description":"\u003cp\u003eNGAL (lipocalin-2) is a lipocalin family protein that plays important roles in innate immunity, inflammation, and atherosclerosis. It was originally identified as a 25 kD protein covalently bound to gelatinase from human neutrophils. NGAL is a critical component of innate immunity because of its ability to bind iron-siderophore complexes and limit bacterial growth. It is also produced by injured epithelia and is one of the most promising markers for renal epithelial injury and cardiovascular disease (CVD).\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant human NGAL\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedIP - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: Clone M0415B7 does not cross-react with mouse NGAL.\u003cbr\u003e\nRRID: AB_2564180 (BioLegend Cat. No. 661902)\u003cbr\u003e\nStructure: 193 amino acid monomer with a predicted molecular weight of approximately 22 kD.\u003cbr\u003e\nDistribution: Secreted by epithelial cells, macrophages, neutrophils; increased levels have been observed in plasma, serum, and urine in various conditions, such as metastatic breast and colorectal cancer, acute kidney injury, pancreatitis and preeclampsia.\u003cbr\u003e\nFunction: Apoptosis, innate immunity, renal development.\u003cbr\u003e\nInteraction: Disulfide-linked with MMP9.\u003cbr\u003e\nLigand\/Receptor: SLC22A17 (24p3R)\u003cbr\u003e\nCell Type: Epithelial cells, Macrophages, Neutrophils\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Biology, Immunology, Innate Immunity, Signal Transduction\u003cbr\u003e\nAntigen References: 1. Iqbal N, et al. 2013. Expert Opin. Med Diagn. 7:209. 2. Singer E, et al. 2013. Acta. Physiol. (Oxf) 207:663. 3. Palazzuoli A, et al. 2012. Clin. Chim. Acta. 413:1832. 4. Flo TH, et al. 2004. Nature 432:917. 5. Goetz DH, et al. 2002. Mol. Cell. 10:1033. 6. Leung L, et al. 2012. PLoS One 7:e46677. 7. Kjeldsen L, et al. 1993. J. Biol. Chem. 268:10425.\u003cbr\u003e\nGene ID: 3934\u003cbr\u003e\nUniProt: View information about NGAL on UniProt.org\u003cbr\u003e\nClone: M0415B7\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Lipocalin 2, Oncogene 24p3, Neutrophil Gelatinase-Associated Lipocalin, Siderocalin LCN2, 25 kD Alpha-2-Microglobulin-Related Subunit Of MMP-9, p25, MSFI, Migration-Stimulating Factor Inhibitor, HNL\u003cbr\u003e\nIsotype: Rat IgG2a, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866123292841,"sku":"661902","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-661902","provider":"Iright","version":"1.0","type":"link"}