{"product_id":"biolegend-670801","title":"Biolegend, 670801, Purified anti-EML4 Antibody, 25μg","description":"\u003cp\u003eEchinoderm microtubule-associated protein-like 4 or EML4 plays a central role in the modification of microtubule structural dynamics and morphology. During mitosis, EML4 expression is upregulated and is associated with spindle formation. In lung cancer cells, a translocation mutation is associated with the EML4 gene, where parts of the gene fuses with the anaplastic lymphoma receptor tyrosine kinase ( ALK ) gene and generates an EML4-ALK fusion protein.\u003cbr\u003e\n25μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Partial recombinant human EML4 protein.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality testedICC - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.05 - 1.0 µg\/mL. For immunocytochemistry, a concentration of 1.0 μg\/mL is recommended. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nApplication Notes: This clone has not been tested for IP.\u003cbr\u003e\nRRID: AB_2814524 (BioLegend Cat. No. 670801) AB_2814525 (BioLegend Cat. No. 670802)\u003cbr\u003e\nStructure: EML4 is a 981 amino acid protein with a predicted molecular weight of 109 kD\u003cbr\u003e\nDistribution: Cytoskeleton\/Ubiquitously expressed\u003cbr\u003e\nFunction: Microtubule formation\u003cbr\u003e\nAntigen References: Yoshida A, et al. 2011. J Thorac Oncol. 10:1677-86. Soda M, et al. 2007. Nature. 448:561. Pollmann M, et al. 2006. Exp Cell Res. (17):3241-51.\u003cbr\u003e\nGene ID: 27436\u003cbr\u003e\nUniProt: View information about EML4 on UniProt.org\u003cbr\u003e\nClone: W18139A\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: EML4, Echinoderm microtubule-associated protein-like 4\u003cbr\u003e\nIsotype: Rat IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866333892777,"sku":"670801","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-670801","provider":"Iright","version":"1.0","type":"link"}