{"product_id":"biolegend-675002","title":"Biolegend, 675002, Purified anti-Leptin Antibody, 100μg","description":"\u003cp\u003eLeptin is primarily synthesized from adipocytes and plays a major role in energy homeostasis and obesity. Leptin resistance has been proposed as a pathophysiological mechanism of obesity. In obese individuals, expression of the short form of the leptin receptor, Ob-Ra, is downregulated, and the individual may be unresponsive to leptin signals. Leptin has also been implicated in the regulation of reproduction, glucose homeostasis, bone formation, hematopoiesis, and wound healing.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human Leptin.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Lee S, et al. 2021. Int J Mol Sci. 22:. PubMed\u003cbr\u003e\nRRID: AB_2565487 (BioLegend Cat. No. 675002)\u003cbr\u003e\nStructure: 167 amino acids with a predicted molecular weight of approximately 18 kD.\u003cbr\u003e\nDistribution: Secreted by adipocytes, gastric epithelial cells, or fibroblasts.\u003cbr\u003e\nFunction: Plays a major role in energy homeostasis and obesity.\u003cbr\u003e\nInteraction: Interacts with Siglec-6.\u003cbr\u003e\nLigand\/Receptor: Leptin receptors.\u003cbr\u003e\nCell Type: Epithelial cells, Fibroblasts\u003cbr\u003e\nBiology Area: Angiogenesis, Cell Biology, Signal Transduction\u003cbr\u003e\nMolecular Family: Enzymes and Regulators\u003cbr\u003e\nAntigen References: 1. Ando S, et al. 2014. Front Oncol. 4:340. 2. Upadhyay J, et al. 2015. Metabolism 64:105. 3. Sainz N, et al. 2015. Metabolism 64:35. 4. Zhang F, et al. 1997. Nature 387:206. 5. Brennan AM, et al. 2006. Nat. Clin. Pract. Endocrinol. Metab. 2:318. 6. Halaas JL, et al. 1995. Science 269:543.\u003cbr\u003e\nGene ID: 3952\u003cbr\u003e\nUniProt: View information about Leptin on UniProt.org\u003cbr\u003e\nClone: M1905E01\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Obese Protein, Obesity Factor, LEPD, OB, OBS\u003cbr\u003e\nIsotype: Mouse IgG2a, λ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866123686057,"sku":"675002","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-675002","provider":"Iright","version":"1.0","type":"link"}