{"product_id":"biolegend-676902","title":"Biolegend, 676902, Purified anti-IL-27 p28 Antibody, 100μg","description":"\u003cp\u003eIL-27 is a heterodimeric cytokine that is composed of two subunits (p28 and EBI3). It plays a critical role in T-cell proliferation and differentiation. It also drives rapid clonal expansion of naive but not memory CD4 T cells. IL-27 is a potent inhibitor of Th17 cell development and IL-17 production. IL-27 subunit p28 alone is able to inhibit the production of IL-17 by CD4 and CD8 T cells. Furthermore, IL-27 plays an important role in antitumor and antiangiogenic activity through the increase in the production of antiangiogenic chemokines such as IP-10\/CXCL10 and MIG\/CXCL9.\u003cbr\u003e\n100μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Mouse\u003cbr\u003e\nImmunogen: Recombinant human IL-27.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.25 - 2.0 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nRRID: AB_2565723 (BioLegend Cat. No. 676902)\u003cbr\u003e\nStructure: A heterodimeric cytokine consisting of EBV-induced gene-3 (EBI3, an IL-12 p40 related protein) and p28 (a newly discovered IL-12 p35-related protein).\u003cbr\u003e\nDistribution: Monocytes, macrophages, and dendritic cells (DCs).\u003cbr\u003e\nFunction: T cell proliferation and differentiation.\u003cbr\u003e\nInteraction: Activated T cells, resting natural killer cells (NK), resting NKT cells, neutrophils, eosinophils, mast cells, hepatic stellate cells, hepatoma cells, and hepatocytes.\u003cbr\u003e\nLigand\/Receptor: IL-27RA, also known as WSX-1 or TCCR, paired with gp130.\u003cbr\u003e\nCell Type: B cells, Dendritic cells, Macrophages, Monocytes\u003cbr\u003e\nBiology Area: Angiogenesis, Apoptosis\/Tumor Suppressors\/Cell Death, Cell Biology, Immunology, Innate Immunity, Signal Transduction\u003cbr\u003e\nMolecular Family: Cytokines\/Chemokines\u003cbr\u003e\nAntigen References: 1. Pflanz S, et al. 2002. Immunity 16:779. 2. Owaki T, et al. 2005. J. Immunol. 175:2191. 3. Batten M, et al. 2006. Nat. Immunol. 7:929. 4. Villarino AV, et al. 2006. J. Immunol. 176:237. 5. Stumhofer JS, et al. 2007. Nat. Immunol. 8:1363. 6. Awasthi A, et al. 2007. Nat. Immunol. 8:1380. 7. Pot C, et al. 2009. J. Immunol. 183:797. 8. Bender H, et al. 2009. Hepatology 50:585. 9. Bosmann M and Ward PA. 2013. J. Leukoc. Biol. 94:1159.\u003cbr\u003e\nGene ID: 246778\u003cbr\u003e\nUniProt: View information about IL-27 on UniProt.org\u003cbr\u003e\nClone: B0315A10\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Interleukin-27 Subunit Alpha, IL-27 (28K subunit)\u003cbr\u003e\nIsotype: Mouse IgG2b, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866080399529,"sku":"676902","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-676902","provider":"Iright","version":"1.0","type":"link"}