{"product_id":"biolegend-677302","title":"Biolegend, 677302, Purified anti-Mac-2 (Galectin-3) Antibody, 500μg","description":"\u003cp\u003eGalectin-3 (galactose-specific lectin 3) is a unique member of the β-galactoside-binding lectin family molecule, which plays an important role in regulation of cell proliferation, differentiation, and tumor cell metastasis. Galectin-3 is mainly found in the cytoplasm, but it is also seen in the nucleus and can be secreted by the non-classical, secretory pathway. In general, secreted galectin-3 mediates cell migration, cell adhesion, and cell-cell interactions through its high affinity binding with galactose-containing glycoproteins on the cell surface. Cytoplasmic galectin-3 exhibits anti-apoptotic activity and regulates several signal transduction pathways, whereas nuclear galectin-3 has been associated with pre-mRNA splicing and gene expression. Recent studies also indicate the potential role of galectin-3 as a biomarker for acute and chronic heart failure.\u003cbr\u003e\n500μg\u003cbr\u003e\nVerified Reactivity: Human\u003cbr\u003e\nAntibody Type: Monoclonal\u003cbr\u003e\nHost Species: Rat\u003cbr\u003e\nImmunogen: Recombinant full-length human Galectin-3.\u003cbr\u003e\nFormulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.\u003cbr\u003e\nPreparation: The antibody was purified by affinity chromatography.\u003cbr\u003e\nConcentration: 0.5 mg\/ml\u003cbr\u003e\nStorage \u0026amp; Handling: The antibody solution should be stored undiluted between 2°C and 8°C.\u003cbr\u003e\nApplication: WB - Quality tested IP - Verified\u003cbr\u003e\nRecommended Usage: Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 2.0 µg per ml. For immunoprecipitation, the suggested use of this reagent is 1-5 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.\u003cbr\u003e\nProduct Citations: Sharma M, et al. 2020. Circ Res. 127:335. PubMed\u003cbr\u003e\nRRID: AB_2565901 (BioLegend Cat. No. 677301) AB_2565902 (BioLegend Cat. No. 677302)\u003cbr\u003e\nStructure: 250 amino acids with a predicted molecular weight of approximately 26 kD.\u003cbr\u003e\nDistribution: Localized in the nucleus, cytoplasm, cell surface, or extracellular matrix. Expressed by tumor cells, monocytes\/macrophages, epithelial cells, Kupffer cells, and dendritic cells.\u003cbr\u003e\nFunction: Regulate cell proliferation, differentiation, adhesion, and anti-apoptosis.\u003cbr\u003e\nInteraction: DMBT1, ITGA3, ITGB1, CSPG4, LGALS3BP, LYPD3, CYHR1, and UACA.\u003cbr\u003e\nLigand\/Receptor: Variety of ligands such as IgE, IgA, galactose, casein kinase I, laminin, mucin, LAMPs, CD66, and etc.\u003cbr\u003e\nCell Type: Dendritic cells\u003cbr\u003e\nBiology Area: Apoptosis\/Tumor Suppressors\/Cell Death, Cell Adhesion, Cell Biology, Cell Cycle\/DNA Replication, Cell Motility\/Cytoskeleton\/Structure, Immunology, Signal Transduction, Transcription Factors\u003cbr\u003e\nMolecular Family: Adhesion Molecules\u003cbr\u003e\nAntigen References: 1. Kim HR, et al. 1999. Cancer Res. 16:4148. 2. Reljic R, et al. 2004. Immunol. Lett. 93:51. 3. Takenaka Y, et al. 2004. Mol. and Cell. Biol. 24:4395. 4. Joo HG, et al. 2001. J Leuko. Biol. 4:555. 5. Gudowska M, et al. 2014. Pol. Merkur. Lekarski. 37:348. 6. Xin M, et al. 2015. Biomed. Pharmacother. 69:179. 7. Filipe MD, et al. 2015. Clin. Chim. Acta. 443:48. 8. Funasaka T, et al. 2014. Glycobiology 24:886.\u003cbr\u003e\nGene ID: 3958\u003cbr\u003e\nUniProt: View information about Mac-2 on UniProt.org\u003cbr\u003e\nClone: M1606B04\u003cbr\u003e\nRegulatory Status: RUO\u003cbr\u003e\nOther Names: Mac-2, Gal-3, RL-29, galactose-specific lectin 3, CBP-35, L-34, εBP\u003cbr\u003e\nIsotype: Rat IgG1, κ\u003c\/p\u003e","brand":"Biolegend","offers":[{"title":"Default Title","offer_id":46866123620521,"sku":"677302","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/biolegend-677302","provider":"Iright","version":"1.0","type":"link"}